ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012
Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Intra-individual Gene Expression Variability of Histologically Normal Breast Tissue.Scientific reports · 2018Trial
- Associations of breast cancer related exposures and gene expression profiles in normal breast tissue-The Norwegian Women and Cancer normal breast tissue study.Cancer reports (Hoboken, N.J.) · 2023Article
- Article
- Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells.Scientific reports · 2022Article
- The DNA damage repair landscape in Black women with breast cancer.Therapeutic advances in medical oncology · 2022Article
- Age-associated genes in human mammary gland drive human breast cancer progression.Breast cancer research : BCR · 2020Article
- Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects.Nature cancer · 2020Article
- A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue.Journal of mammary gland biology and neoplasia · 2019Article
- Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: use case in breast carcinogenesis.Computational toxicology (Amsterdam, Netherlands) · 2018Article
- Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue.Stem cell reports · 2018Article
- Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue.PloS one · 2018Article
- Identifying disease-associated pathways in one-phenotype data based on reversal gene expression orderings.Scientific reports · 2017Article
- p16 loss rescues functional decline of Brca1-deficient mammary stem cells.Cell cycle (Georgetown, Tex.) · 2017Article
- Integrative analysis of pathway deregulation in obesity.NPJ systems biology and applications · 2017Article
- Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling.Oncotarget · 2016Article
- Cell Fate Decisions During Breast Cancer Development.Journal of developmental biology · 2016Article
- Digital histologic analysis reveals morphometric patterns of age-related involution in breast epithelium and stroma.Human pathology · 2016Article
- Genomic aberrations in young and elderly breast cancer patients.BMC medicine · 2015Article
- Race-associated biological differences among Luminal A breast tumors.Breast cancer research and treatment · 2015Article
- Tumor intrinsic subtype is reflected in cancer-adjacent tissue.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundAge is the strongest breast cancer risk factor, with overall breast cancer risk increasing steadily beginning at approximately 30 years of age. However, while breast cancer risk is lower among younger women, young women's breast cancer may be more aggressive. Although, several genomic and epidemiologic studies have shown higher prevalence of aggressive, estrogen-receptor negative breast cancer in younger women, the age-related gene expression that predisposes to these tumors is poorly understood. Characterizing age-related patterns of gene expression in normal breast tissues may provide insights on etiology of distinct breast cancer subtypes that arise from these tissues.
methodsTo identify age-related changes in normal breast tissue, 96 tissue specimens from patients with reduction mammoplasty, ages 14 to 70 years, were assayed by gene expression microarray.
resultsSignificant associations between gene expression levels and age were identified for 802 probes (481 increased, 321 decreased with increasing age). Enriched functions included "aging of cells," "shape change," and "chemotaxis," and enriched pathways included Wnt/beta-catenin signaling, Ephrin receptor signaling, and JAK/Stat signaling. Applying the age-associated genes to publicly available tumor datasets, the age-associated pathways defined two groups of tumors with distinct survival.
conclusionThe hazard rates of young-like tumors mirrored that of high-grade tumors in the Surveillance, Epidemiology, and End Results Program, providing a biologic link between normal aging and age-related tumor aggressiveness. IMPACT: These data show that studies of normal tissue gene expression can yield important insights about the pathways and biologic pressures that are relevant during tumor etiology and progression.
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