ArticleSmall GTPases
ROCKs cause SHP-wrecks and broken hearts.
Article in Small GTPases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
Abstract
During embryogenesis, the heart is one of the first organs to develop. Its formation requires a complex combination of migration of cardiac precursors to the ventral midline coupled with the fusion of these cardiogenic fields and subsequent cellular reorganization to form a linear heart tube. A finely controlled choreography of cell proliferation, adhesion, contraction and movement drives the heart tube to loop and subsequently septate to form the four-chambered mammalian heart we are familiar with. Defining how this plethora of cellular processes is controlled both spatially and temporally is a scientific feat that has fascinated researchers for decades. Unfortunately, the complex nature of this organ's development also makes it a prime target for mutation-induced malformation, as evidenced by the multitude of prevalent congenital heart disorders identified that afflict up to 1% of the population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.