ArticleDiagnostic microbiology and infectious disease2012
Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007.
Article in Diagnostic microbiology and infectious disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
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- Determination of ESBLs, pAmpC-beta-lactamase genes, and plasmid replicon types amongArchives of Razi Institute · 2025Article
- Development of a Novel mRNA Vaccine AgainstBioinformatics and biology insights · 2025Article
- Toward aInternational journal of molecular sciences · 2023Review
- Prevalence of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Review
- High frequency of antimicrobial resistance and virulence gene in Shigella species isolated from pediatric patients in an Iranian Referral Hospital.Acta bio-medica : Atenei Parmensis · 2022Article
- Occurrence of Potentially Pathogenic Bacteria in Epilithic Biofilm Forming Bacteria isolated from Porter Brook River-stones, Sheffield, UK.Saudi journal of biological sciences · 2020Review
- Antimicrobial resistance and genetic characterization of Shigella spp. in Shanxi Province, China, during 2006-2016.BMC microbiology · 2019Article
- Article
- Molecular characterization of fluoroquinolone and/or cephalosporin resistance in Shigella sonnei isolates from yaks.BMC veterinary research · 2018Article
- Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.PloS one · 2018Article
- A Study of prevalence ofIranian journal of microbiology · 2017Article
- A 10-year surveillance of antimicrobial susceptibility patterns in Shigella sonnei isolates circulating in Jiangsu Province, China.Journal of global antimicrobial resistance · 2017Article
- First report of the qnrA determinant in Shigella sonnei isolated from China.Epidemiology and infection · 2017Article
- A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015.Antimicrobial agents and chemotherapy · 2017Article
- Epidemic characterization and molecular genotyping ofAntimicrobial resistance and infection control · 2017Article
- Association between meteorological factors and bacillary dysentery incidence in Chaoyang city, China: an ecological study.BMJ open · 2016Article
- Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.Scientific reports · 2016Article
- The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants.Vaccine · 2016Article
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10 authors.
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Abstract
Shigella sonnei has become the dominant serotype causing shigellosis in Asian countries in recent years. In this study, we characterize the increasing trend of antibiotic resistance profiles and genotypes of S. sonnei isolates in the Beijing area. From January 2002 to December 2007, a total of 1108 Shigella isolates including 362 S. sonnei were recovered from diarrhea patients at the 302nd Hospital in Beijing. While the frequency of S. flexneri gradually decreased, S. sonnei gradually increased and became the dominant species. A total of 362 S. sonnei isolates were further analyzed for their antimicrobial profiles and 272 revived isolates were selected for genotyping analysis, respectively. High-level antimicrobial resistances were observed in sulfamethoxazole/trimethoprim (94.5%), ampicillin (40.3%), piperacillin (36.5%), and ceftriaxone (12.8%) with significant single- and multiple-drug resistance increase trends from 2002 to 2007 (P = 0.0000). Pulsed-field gel electrophoresis analysis indicated that 263 (96.7%) S. sonnei belonged to 1 clonal genotype A, which were further divided into A1-A6 subtypes. While subtype A2 was dominant in the early stage of study years, subtype A4 started to emerge and increased significantly in later years. Antimicrobial resistance rates are statistically different among the 6 subtypes (P = 0.0000), and A4 possessed the highest resistance rates to ampicillin (83.7%) and piperacillin (81.4%). Subtype A3 was highly clustered in inpatients compared to other subtypes (P = 0.0145). This study indicates that a clonal S. sonnei strain has become dominant in the Beijing area, and subtype A4 is responsible for increased antibiotic resistance.
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