ArticleDevelopmental and comparative immunology2012
Manduca sexta gloverin binds microbial components and is active against bacteria and fungi.
Article in Developmental and comparative immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Interplay ofVirulence · 2025Article
- Identification and expression of a novel antimicrobial peptide Gloverin and its antibacterial effect against Staphylococcus aureus.BMC microbiology · 2025Article
- Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review.International journal of molecular sciences · 2024Review
- The antifungal peptide AnAFP fromFrontiers in microbiology · 2024Article
- In vitro anticancer potential of laminarin and fucoidan from Brown seaweeds.Scientific reports · 2023Article
- Article
- A Straightforward Method for the Isolation and Cultivation ofInternational journal of molecular sciences · 2022Article
- Evaluation of antibacterial activity induced bySaudi journal of biological sciences · 2022Article
- Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance.Cellular and molecular life sciences : CMLS · 2021Review
- Suppression of Calcineurin Enhances the Toxicity of Cry1Ac toFrontiers in microbiology · 2021Article
- Article
- Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development ofFrontiers in physiology · 2019Article
- Epigenetic Mechanisms Are Involved in Sex-SpecificFrontiers in physiology · 2019Article
- Antibacterial Mechanism of Gloverin2 from Silkworm,International journal of molecular sciences · 2018Article
- Optimized expression of the antimicrobial protein Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells.Cytotechnology · 2017Article
- Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta.Developmental and comparative immunology · 2016Article
- Diversity, evolution and medical applications of insect antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta.Scientific reports · 2016Article
- Molecular cloning and characterization of gloverin from the diamondback moth, Plutella xylostella L. and its interaction with bacterial membrane.World journal of microbiology & biotechnology · 2015Article
- Genome-wide characterization and expression profiling of immune genes in the diamondback moth, Plutella xylostella (L.).Scientific reports · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Hyalophora gloveri gloverin is a glycine-rich and heat stable antimicrobial protein with activity mainly against Escherichia coli. However, Spodoptera exigua gloverin is active against a Gram-positive bacterium but inactive against E. coli. In this study, we investigated expression profile, binding ability and antimicrobial activity of Manduca sexta gloverin (MsGlv). Msglv transcript was detected in several tissues of naïve larvae with higher levels in the midgut and testis. Expression of Msglv mRNA in larvae was up-regulated by active Spätzle-C108 and peptidoglycans (PGs) of E. coli and Staphylococcus aureus, and the activation was blocked by pre-injection of antibody to M. sexta Toll, suggesting that Msglv expression is regulated by the Toll-Spätzle pathway. Recombinant MsGlv bound to the O-specific antigen and outer core carbohydrate of lipopolysaccharide (LPS), Gram-positive lipoteichoic acid (LTA) and PG, and laminarin, but not to E. coli PG or mannan. MsGlv was active against Bacillus cereus, Saccharomyces cerevisiae and Cryptococcus neoformans, but was almost inactive against E. coli and S. aureus. Our results suggest that gloverins are active against some bacteria and fungi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.