ArticleJournal of psychiatric research2012
Testosterone levels in suicide attempters with bipolar disorder.
Article in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder.The Australian and New Zealand journal of psychiatry · 2015Pooled it
- Anabolic-androgenic steroid use and psychopathology in athletes. A systematic review.Current neuropharmacology · 2015Pooled it
- Testosterone in patients with borderline personality disorder: from hair analyses to social behavior.Comprehensive psychoneuroendocrinology · 2026Review
- Neuroendocrine abnormalities as predictors of suicidal ideation in bipolar disorder patients during depressive episodes: a cross-sectional study.BMC psychiatry · 2025Article
- A multiagent reinforcement learning algorithm for personalized recommendations in bipolar disorder.PNAS nexus · 2025Article
- High testosterone levels associated with elevated suicidal risk in male adolescents with depression.BMC psychiatry · 2025Article
- Trace Lithium for Suicide Prevention and Dementia Prevention: A Qualitative Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Salivary testosterone is associated with feelings of senselessness and self-dislike in women with borderline personality disorder.European journal of psychotraumatology · 2024Article
- Article
- Hormonal and inflammatory signatures of different mood episodes in bipolar disorder: a large-scale clinical study.BMC psychiatry · 2023Article
- Testosterone and Suicidal Behavior in Bipolar Disorder.International journal of environmental research and public health · 2023Article
- Demographic, clinical and biochemical correlates of the length of stay for different polarities in Chinese inpatients with bipolar disorder: A real-world study.Frontiers in human neuroscience · 2023Article
- The association of hypogonadism with depression and its treatments.Frontiers in endocrinology · 2023Review
- Bipolar spectrum disorders are associated with increased gray matter volume in the medial orbitofrontal cortex and nucleus accumbens.JCPP advances · 2022Article
- Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty.Molecular psychiatry · 2022Review
- Relationship between thyroid hormone and sex hormone levels and non-suicidal self-injury in male adolescents with depression.Frontiers in psychiatry · 2022Article
- New frontiers in suicide vulnerability: immune system and sex hormones.Brain, behavior, & immunity - health · 2021Article
- Review
- Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review).Experimental and therapeutic medicine · 2020Review
- Positive Affect Moderates the Relationship Between Salivary Testosterone and a Health Behavior Composite in University Females.International journal of behavioral medicine · 2020Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe best known neurobehavioral effects of testosterone are on sexual function and aggression. However, testosterone and other androgens may be involved in the pathophysiology of mood disorders and suicidal behavior. This is the first study to examine whether there is a relation between testosterone levels and clinical parameters in bipolar suicide attempters.
methodsPatients with a DSM-IV diagnosis of a bipolar disorder (16 males and 51 females), in a depressive or mixed episode with at least one past suicide attempt were enrolled. Demographic and clinical parameters, including lifetime suicidal behavior, were assessed and recorded. Plasma testosterone was assayed using a double antibody radioimmunoassay procedure.
resultsThe number of major depressive episodes, the maximum lethality of suicide attempts, and the testosterone levels were higher in men compared to women. Current suicidal ideation scores were higher in women compared to men. Controlling for sex, we found that testosterone levels positively correlated with the number of manic episodes and the number of suicide attempts.
conclusionOur findings are consistent with previous observations of the association between testosterone levels and parameters of mood and behavior. This study suggests that testosterone levels may be related to the course of bipolar disorder and suicidal behavior. Further studies of the role of testosterone in the neurobiology of mood disorders and suicidal behavior are merited.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.