ReviewMaturitas2012
Estrogens, hormone therapy, and hippocampal volume in postmenopausal women.
Review in Maturitas, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Cognitive complaints are associated with smaller right medial temporal gray-matter volume in younger postmenopausal women.Menopause (New York, N.Y.) · 2020Trial
- Trial
- Early midlife ovarian removal is associated with lower posterior hippocampal function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An Investigation on Modifiable and Nonmodifiable Estrogen Exposure and Gray Matter Volume in Healthy Older Women.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer's Disease Implications.Life (Basel, Switzerland) · 2024Review
- Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank.Human brain mapping · 2024Article
- Women's Brain Health: Midlife Ovarian Removal Affects Associative Memory.Molecular neurobiology · 2023Article
- Article
- Estrogen, brain structure, and cognition in postmenopausal women.Human brain mapping · 2021Article
- Social subordination alters estradiol-induced changes in cortico-limbic brain volumes in adult female rhesus monkeys.Psychoneuroendocrinology · 2020Article
- A Classic Herbal Formula Guizhi Fuling Wan for Menopausal Hot Flushes: From Experimental Findings to Clinical Applications.Biomedicines · 2019Review
- Impact of sex steroids and reproductive stage on sleep-dependent memory consolidation in women.Neurobiology of learning and memory · 2019Review
- Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.Human brain mapping · 2019Article
- Sex differences in hippocampal cognition and neurogenesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Estrogen enhances hippocampal gray-matter volume in young and older postmenopausal women: a prospective dose-response study.Neurobiology of aging · 2017Article
- Bone Mineral Density and Cognitive Decline in Elderly Women: Results from the InCHIANTI Study.Calcified tissue international · 2016Article
- Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder.Current psychiatry reports · 2015Review
- Article
- Menopausal hot flashes and the default mode network.Fertility and sterility · 2015Article
- Functional and molecular neuroimaging of menopause and hormone replacement therapy.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The brain atrophies in late life. However, there are many factors that either magnify or mitigate the rate of atrophy. Loss of estrogens during menopause and administration of hormone therapy have both been hypothesized as sources of individual variation in the prevalence of cortical and subcortical atrophy and loss of cognitive function in late adulthood. In this review we critically summarize and assess the extant rodent and human neuroimaging studies that examine the link between estrogens and hippocampal morphology and function and focus predominantly on human studies of the hippocampus in postmenopausal women. Several cross-sectional studies report that the size of the hippocampus is larger in women receiving hormone therapy while several other cross-sectional studies report either negligible effects or smaller volumes in women receiving hormone therapy. We suggest that these differences might be caused by the variation between studies in the age of the samples studied, the duration of therapy, and the age at which hormone therapy is initiated. Unfortunately, all of the human studies reviewed here are cross-sectional in nature. With the lack of well-controlled randomized trials with neuroimaging measures on postmenopausal women both before and after some exposure interval, the effect of hormone therapy on hippocampal atrophy will remain equivocal and poorly understood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.