ReviewCurrent opinion in immunology2012
Using epigenetic mechanisms to understand the impact of common disease causing alleles.
Review in Current opinion in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- TRPC7 facilitates cell growth and migration by regulating intracellular CaOncology letters · 2023Article
- Factors and molecules that could impact cell differentiation in the embryo generated by nuclear transfer.Organogenesis · 2017Review
- Epigenetics and inheritance of phenotype variation in livestock.Epigenetics & chromatin · 2016Review
- Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Recent developments in epigenetics of acute and chronic kidney diseases.Kidney international · 2015Review
- Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes.Epigenetics · 2015Article
- Dissecting the causal genetic mechanisms of coronary heart disease.Current atherosclerosis reports · 2014Review
- Association of low-protein supplemented diets with fetal growth in pregnant women with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.Diabetes · 2014Article
- Epigenetics: the fine-tuner in inflammatory bowel disease?Current opinion in gastroenterology · 2013Review
- Epigenetic modifications in the pathogenesis of diabetic nephropathy.Seminars in nephrology · 2013Review
- Article
- Systematic classification of non-coding RNAs by epigenomic similarity.BMC bioinformatics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Many common genetic variants have been identified to be associated with autoimmune diseases such as Type I diabetes. Methods to identify these genetic loci have become powerful, but deciphering the functional effects of these variants in disease progression remains a major challenge. Recent studies have shown that single nucleotide polymorphisms are associated with altered DNA methylation and chromatin accessibility, suggesting that genetic variants can alter epigenetic features and epigenetic variations can mediate genetic variability. In this review, we highlight recent studies that have examined the relationship between genetics and epigenetics, and how epigenetic studies may complement genetic studies in understanding the impact of common disease causing alleles.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.