ArticleOrganic letters2012
Synthesis of frame-shifted farnesyl diphosphate analogs.
Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Organotellurium Probes Enable One-step Single-cell Analysis of Post-translational Modification.Journal of the American Chemical Society · 2026Article
- Enantioselective Ir-Catalyzed Hydrogenation of Terminal Homoallyl Sulfones: Total Synthesis of (-)-Curcumene.Organic letters · 2023Article
- Studies toward brevisulcenal F via convergent strategies for marine ladder polyether synthesis.Tetrahedron · 2018Article
- Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.Organic letters · 2016Article
- Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.Bioorganic & medicinal chemistry letters · 2016Article
- Fluorescent probes for investigation of isoprenoid configuration and size discrimination by bactoprenol-utilizing enzymes.Bioorganic & medicinal chemistry · 2013Article
- Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.Biochemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A set of synthetic approaches were developed and applied to the synthesis of eight frame-shifted farnesyl diphosphate (FPP) analogs. These analogs bear increased or decreased methylene units between the double bonds and/or diphosphate moieties of the isoprenoid structure. Evaluation versus mammalian FTase revealed that small structural changes can lead to dramatic changes in substrate ability.
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Registered trials
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