ArticleBMC genomics2012
The receptor like kinase at Rhg1-a/Rfs2 caused pleiotropic resistance to sudden death syndrome and soybean cyst nematode as a transgene by altering signaling responses.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- From Morphology to Multi-Omics: A New Age of Fusarium Research.Pathogens (Basel, Switzerland) · 2025Review
- Deciphering the genetic architecture of resistance toFrontiers in plant science · 2023Article
- Breeding for disease resistance in soybean: a global perspective.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Enhanced resistance to soybean cyst nematode in transgenic soybean via host-induced silencing of vital Heterodera glycines genes.Transgenic research · 2022Article
- Genetic Diversity and Selection Footprints in the Genome of Brazilian Soybean Cultivars.Frontiers in plant science · 2022Article
- Molecular mapping of quantitative disease resistance loci for soybean partial resistance to Phytophthora sansomeana.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Molecular Basis of Soybean Resistance to Soybean Aphids and Soybean Cyst Nematodes.Plants (Basel, Switzerland) · 2019Review
- Effective identification of soybean candidate genes involved in resistance to soybean cyst nematode via direct whole genome re-sequencing of two segregating mutants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- QTL mapping and epistatic interaction analysis of field resistance to sudden death syndrome (Fusarium virguliforme) in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Field evaluation of three sources of genetic resistance to sudden death syndrome of soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Mapping of new quantitative trait loci for sudden death syndrome and soybean cyst nematode resistance in two soybean populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Integration of sudden death syndrome resistance loci in the soybean genome.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Review
- 'MN1606SP' by 'Spencer' filial soybean population reveals novel quantitative trait loci and interactions among loci conditioning SDS resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- QTLomics in Soybean: A Way Forward for Translational Genomics and Breeding.Frontiers in plant science · 2016Review
- Genetic characteristics of soybean resistance to HG type 0 and HG type 1.2.3.5.7 of the cyst nematode analyzed by genome-wide association mapping.BMC genomics · 2015Article
- Soybean kinome: functional classification and gene expression patterns.Journal of experimental botany · 2015Article
- Article
- Orthologous plant microRNAs: microregulators with great potential for improving stress tolerance in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Review
- Genome-wide association mapping of quantitative resistance to sudden death syndrome in soybean.BMC genomics · 2014Article
- Usefulness of 10 genomic regions in soybean associated with sudden death syndrome resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoybean (Glycine max (L. Merr.)) resistance to any population of Heterodera glycines (I.), or Fusarium virguliforme (Akoi, O'Donnell, Homma & Lattanzi) required a functional allele at Rhg1/Rfs2. H. glycines, the soybean cyst nematode (SCN) was an ancient, endemic, pest of soybean whereas F. virguliforme causal agent of sudden death syndrome (SDS), was a recent, regional, pest. This study examined the role of a receptor like kinase (RLK) GmRLK18-1 (gene model Glyma_18_02680 at 1,071 kbp on chromosome 18 of the genome sequence) within the Rhg1/Rfs2 locus in causing resistance to SCN and SDS.
resultsA BAC (B73p06) encompassing the Rhg1/Rfs2 locus was sequenced from a resistant cultivar and compared to the sequences of two susceptible cultivars from which 800 SNPs were found. Sequence alignments inferred that the resistance allele was an introgressed region of about 59 kbp at the center of which the GmRLK18-1 was the most polymorphic gene and encoded protein. Analyses were made of plants that were either heterozygous at, or transgenic (and so hemizygous at a new location) with, the resistance allele of GmRLK18-1. Those plants infested with either H. glycines or F. virguliforme showed that the allele for resistance was dominant. In the absence of Rhg4 the GmRLK18-1 was sufficient to confer nearly complete resistance to both root and leaf symptoms of SDS caused by F. virguliforme and provided partial resistance to three different populations of nematodes (mature female cysts were reduced by 30-50%). In the presence of Rhg4 the plants with the transgene were nearly classed as fully resistant to SCN (females reduced to 11% of the susceptible control) as well as SDS. A reduction in the rate of early seedling root development was also shown to be caused by the resistance allele of the GmRLK18-1. Field trials of transgenic plants showed an increase in foliar susceptibility to insect herbivory.
conclusionsThe inference that soybean has adapted part of an existing pathogen recognition and defense cascade (H.glycines; SCN and insect herbivory) to a new pathogen (F. virguliforme; SDS) has broad implications for crop improvement. Stable resistance to many pathogens might be achieved by manipulation the genes encoding a small number of pathogen recognition proteins.
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