Trial reportItalian journal of pediatrics2012
Role of zinc in severe pneumonia: a randomized double bind placebo controlled study.
Trial report in Italian journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Emergency care interventions for paediatric severe acute respiratory infections in low- and middle-income countries: A systematic review and narrative synthesis.Journal of global health · 2023Pooled it
- Efficacy of zinc as adjunctive pneumonia treatment in children aged 2 to 60 months in low-income and middle-income countries: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Zinc supplements for preventing otitis media.The Cochrane database of systematic reviews · 2014Pooled it
- Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial.Biological trace element research · 2021Trial
- Effect of zinc supplementation on infants with severe pneumonia.World journal of pediatrics : WJP · 2016Trial
- Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia.Journal of tropical pediatrics · 2014Trial
- The Role of Zinc Against Bacterial Infections in Neonates, Children, and Adults: A Scoping Review from the Available Evidence of Randomized Controlled Trials About Zinc Supplementation to New Research Opportunities.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Investigating the Efficacy of Zinc and Vitamin A in Treating Pediatric Community-Acquired Pneumonia.Cureus · 2024Article
- Zinc in Human Health and Infectious Diseases.Biomolecules · 2022Review
- Review of the role of additional treatments including oseltamivir, oral steroids, macrolides, and vitamin supplementation for children with severe pneumonia in low- and middle-income countries.Journal of global health · 2022Review
- Effect of zinc versus vitamin A supplementation on pediatric patients with community-acquired pneumonia.Frontiers in pharmacology · 2022Article
- Review
- Zinc against COVID-19? Symptom surveillance and deficiency risk groups.PLoS neglected tropical diseases · 2021Review
- Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights.Redox biology · 2021Review
- The Role of Micronutrients in Support of the Immune Response against Viral Infections.Nutrients · 2020Review
- Effect of traditional Chinese medicine injections on severe pneumonia: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- Role of Zinc Supplementation in the Improvement of Acute Respiratory Infections among Iranian Children: A Systematic Review.Tanaffos · 2020Review
- Article
- Zinc Supplementation in Adult Mechanically Ventilated Trauma Patients is Associated with Decreased Occurrence of Ventilator-associated Pneumonia: A Secondary Analysis of a Prospective, Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumonia is a leading cause of morbidity and mortality in children.
objectiveThe aim of study was to evaluate the efficacy of Zinc supplementation in treatment of severe pneumonia in hospitalized children. DESIGN/
methodsA double blind randomized, placebo- controlled clinical trial conducted at a tertiary care centre of a teaching hospital. Children with diagnosis of severe pneumonia were randomly assigned to receive supplementation with either elemental zinc or placebo by mouth at the time of enrollment. From day 2, they received 10 mg of their assigned treatment by mouth twice a day for 7 days along with standard antimicrobial therapy.
resultsThe baseline characteristics like age, sex, weight, weight Z score, height, height Z score, weight for height Z score and hemoglobin were comparable in both study groups. The respiratory rate, chest indrawing, cyanosis, stridor, nasal flaring, wheeze and fever in both groups recorded at enrollment and parameters did not differ significantly between the two groups. The outcome measures like time taken for resolution of severe pneumonia, pneumonia, duration of hospital stay, nil per oral, intravenous fluid, oxygen use, treatment requiring 2nd line of drug and 3rd line drug were evaluated and found to be same.
conclusionThe present study did not show a statistically significant reduction in duration of severe pneumonia, or reduction in hospital stay for children given daily zinc supplementation along with standard antimicrobial therapy. Therefore, zinc supplementation given during the acute episode does not help in short term clinical recovery from severe pneumonia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.