ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2012
Heritability of multivariate gray matter measures in schizophrenia.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural covariance networks in schizophrenia: A systematic review Part I.Schizophrenia research · 2022Pooled it
- From form to concept: a dynamic spatiotemporal brain network cascade supports language comprehension.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Source-based morphometry analyses yield associations between large-scale structural brain networks and psychopathic traits in incarcerated adolescents.Frontiers in psychology · 2026Article
- Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study.Psychiatry research. Neuroimaging · 2025Article
- Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson's disease: a multisite functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2025Article
- dcSBM: A federated constrained source-based morphometry approach for multivariate brain structure mapping.Human brain mapping · 2023Article
- Rapid Interactions of Widespread Brain Networks Characterize Semantic Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Gene Expressions Preferentially Influence Cortical Thickness of Human Connectome Project Atlas Parcellated Regions in First-Episode Antipsychotic-Naïve Psychoses.Schizophrenia bulletin open · 2023Article
- Disturbed hippocampal intra-network in first-episode of drug-naïve major depressive disorder.Brain communications · 2023Article
- Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach.Frontiers in human neuroscience · 2022Article
- Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia.Psychiatry research · 2021Article
- Spatially Covarying Patterns of Gray Matter Volume and Concentration Highlight Distinct Regions in Schizophrenia.Frontiers in neuroscience · 2021Article
- N-BiC: A Method for Multi-Component and Symptom Biclustering of Structural MRI Data: Application to Schizophrenia.IEEE transactions on bio-medical engineering · 2020Article
- Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients.Journal of molecular cell biology · 2019Article
- Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.Schizophrenia bulletin · 2019Article
- Machine learning of brain gray matter differentiates sex in a large forensic sample.Human brain mapping · 2019Article
- Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia.Frontiers in neuroscience · 2019Article
- Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition.NeuroImage. Clinical · 2018Article
- Ten Key Observations on the Analysis of Resting-state Functional MR Imaging Data Using Independent Component Analysis.Neuroimaging clinics of North America · 2017Review
- Familial and environmental influences on brain volumes in twins with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2017Article
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14 authors.
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Abstract
Structural brain measures are employed as endophenotypes in the search for schizophrenia susceptibility genes. We analyzed two independent structural imaging datasets with voxel-based morphometry and with source-based morphometry, a multivariate, independent components analysis, to determine the stability and heritability of regional gray matter concentration abnormalities in schizophrenia. The samples comprised 209 and 102 patients with schizophrenia and 208 and 96 healthy volunteers, respectively. The second sample additionally included non-ill siblings of participants with and without schizophrenia. A standard voxel-based analysis showed reproducible regional gray matter deficits in the affected participants compared with unrelated, unaffected controls in both datasets: patients showed significant gray matter concentration deficits in cortical frontal, temporal, and insular lobes. Source-based morphometry (SBM) was applied to the gray matter images of the entire sample to determine the effects of diagnosis on networks of covarying structures. The SBM analysis extracted 24 significant sets of covarying regions (components). Four of these components showed significantly lower gray matter concentrations in patients (p < .05). We determined the familiality of the observed SBM components based on 66 sibling pairs (25 discordant for schizophrenia). Two components, one including the medial frontal, insular, inferior frontal, and temporal lobes, and the other including the posterior occipital lobe, showed significant familiality (p < .05). We conclude that structural brain deficits in schizophrenia are replicable, and that SBM can extract unique familial and likely heritable components. SBM provides a useful data reduction technique that can provide measures that may serve as endophenotypes for schizophrenia.
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