ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2012
Genetic contributions to the midsagittal area of the corpus callosum.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.Human brain mapping · 2016Pooled it
- Heritability in corpus callosum morphology and its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations.Genes, brain, and behavior · 2022Article
- The role of early social rearing, neurological, and genetic factors on individual differences in mutual eye gaze among captive chimpanzees.Scientific reports · 2020Article
- Functional network connectivity impairments and core cognitive deficits in schizophrenia.Human brain mapping · 2019Article
- White Matter in Schizophrenia Treatment Resistance.The American journal of psychiatry · 2019Article
- Miniature pig model of human adolescent brain white matter development.Journal of neuroscience methods · 2018Article
- Integration of routine QA data into mega-analysis may improve quality and sensitivity of multisite diffusion tensor imaging studies.Human brain mapping · 2018Article
- Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.Biological psychiatry · 2016Article
- The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.NeuroImage · 2016Article
- Behavioral and brain asymmetries in primates: a preliminary evaluation of two evolutionary hypotheses.Annals of the New York Academy of Sciences · 2015Review
- Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia.Human brain mapping · 2015Article
- Genetic basis in motor skill and hand preference for tool use in chimpanzees (Pan troglodytes).Proceedings. Biological sciences · 2015Article
- Chimpanzee intelligence is heritable.Current biology : CB · 2014Article
- Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.PloS one · 2014Article
- Neuroimaging and genetics: exploring, searching, and finding.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
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5 authors.
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Abstract
The degree to which genes and environment determine variations in brain structure and function is fundamentally important to understanding normal and disease-related patterns of neural organization and activity. We studied genetic contributions to the midsagittal area of the corpus callosum (CC) in pedigreed baboons (68 males, 112 females) to replicate findings of high genetic contribution to that area of the CC reported in humans, and to determine if the heritability of the CC midsagittal area in adults was modulated by fetal development rate. Measurements of callosal area were obtained from high-resolution MRI scans. Heritability was estimated from pedigree-based maximum likelihood estimation of genetic and non-genetic variance components as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Our analyses revealed significant heritability for the total area of the CC and all of its subdivisions, with h2 = .46 for the total CC, and h2 = .54, .37, .62, .56, and .29 for genu, anterior midbody, medial midbody, posterior midbody and splenium, respectively. Genetic correlation analysis demonstrated that the individual subdivisions shared between 41% and 98% of genetic variability. Combined with previous research reporting high heritability of other brain structures in baboons, these results reveal a consistent pattern of high heritability for brain morphometric measures in baboons.
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