ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2012
Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Heritability of Subcortical Grey Matter Structures.Medicina (Kaunas, Lithuania) · 2022Article
- Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer's Disease.Frontiers in immunology · 2021Article
- Alzheimer's Disease Risk Variant rs2373115 Regulates GAB2 and NARS2 Expression in Human Brain Tissues.Journal of molecular neuroscience : MN · 2018Article
- The impact ofAnnals of translational medicine · 2018Article
- Translational Meta-analytical Methods to Localize the Regulatory Patterns of Neurological Disorders in the Human Brain.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2015Article
- Whole-genome analyses of whole-brain data: working within an expanded search space.Nature neuroscience · 2014Review
- Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.Brain imaging and behavior · 2014Review
- On the other hand: including left-handers in cognitive neuroscience and neurogenetics.Nature reviews. Neuroscience · 2014Review
- Article
- Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression.Frontiers in neuroscience · 2012Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27-1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.
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