ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Experience-dependent switch in sign and mechanisms for plasticity in layer 4 of primary visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
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- A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types.Nature communications · 2025Article
- Metastable dynamics of neural circuits and networks.Applied physics reviews · 2022Review
- Presynaptic NMDA Receptors Influence CaNeural plasticity · 2022Article
- Implications of Extended Inhibitory Neuron Development.International journal of molecular sciences · 2021Review
- Decreased reproducibility and abnormal experience-dependent plasticity of network dynamics in Fragile X circuits.Scientific reports · 2020Article
- Brief period of monocular deprivation drives changes in audiovisual temporal perception.Journal of vision · 2020Article
- Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity.eLife · 2020Article
- The BDNF Val66Met Polymorphism Promotes Changes in the Neuronal Integrity and Alters the Time Perception.Journal of molecular neuroscience : MN · 2019Review
- Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biological psychiatry · 2017Review
- Early Cross-modal Plasticity in Adults.Journal of cognitive neuroscience · 2017Article
- Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.Brain structure & function · 2016Article
- Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.Trends in neurosciences · 2016Review
- Article
- Synapse-type-specific plasticity in local circuits.Current opinion in neurobiology · 2015Review
- Competition, inhibition, and critical periods of cortical plasticity.Current opinion in neurobiology · 2015Review
- Delayed in vitro development of Up states but normal network plasticity in Fragile X circuits.The European journal of neuroscience · 2015Article
- A model of order-selectivity based on dynamic changes in the balance of excitation and inhibition produced by short-term synaptic plasticity.Journal of neurophysiology · 2015Article
- Models of Metaplasticity: A Review of Concepts.Frontiers in computational neuroscience · 2015Review
- Target-specific properties of thalamocortical synapses onto layer 4 of mouse primary visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
Neural circuits are extensively refined by sensory experience during postnatal development. How the maturation of recurrent cortical synapses may contribute to events regulating the postnatal refinement of neocortical microcircuits remains controversial. Here we show that, in the main input layer of rat primary visual cortex, layer 4 (L4), recurrent excitatory synapses are endowed with multiple, developmentally regulated mechanisms for induction and expression of excitatory synaptic plasticity. Maturation of L4 synapses and visual experience lead to a sharp switch in sign and mechanisms for plasticity at recurrent excitatory synapses in L4 at the onset of the critical period for visual cortical plasticity. The state of maturation of excitatory pyramidal neurons allows neurons to engage different mechanisms for plasticity in response to the same induction paradigm. Experience is determinant for the maturation of L4 synapses, as well as for the transition between forms of plasticity and the mechanisms they may engage. These results indicate a tight correlation between the effects of sensory drive and maturation on cortical neurons and provide a new set of cellular mechanisms engaged in the postnatal refinement of cortical circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.