ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Taste coding in the nucleus of the solitary tract of the awake, freely licking rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Altered eating experience during GLP-1 receptor agonist therapy: a sensory-liking-wanting framework for food preference and nutritional behaviour.Frontiers in nutrition · 2026Review
- Computational Advances in Taste Perception: From Ion Channels and Taste Receptors to Neural Coding.Brain sciences · 2025Article
- Electrophysiological responses to appetitive and consummatory behavior in the rostral nucleus tractus solitarius in awake, unrestrained rats.bioRxiv : the preprint server for biology · 2024Article
- Locus Ceruleus Dynamics Are Suppressed during Licking and Enhanced Postlicking Independent of Taste Novelty.eNeuro · 2024Article
- Electrophysiological responses to appetitive and consummatory behavior in the rostral nucleus tractus solitarius in awake, unrestrained rats.Frontiers in integrative neuroscience · 2024Article
- Synaptic loss and gliosis in the nucleus tractus solitarii with streptozotocin-induced Alzheimer's disease.Brain research · 2023Article
- Oral thermal processing in the gustatory cortex of awake mice.Chemical senses · 2023Article
- Multisensory integration of orally-sourced gustatory and olfactory inputs to the posterior piriform cortex in awake rats.The Journal of physiology · 2023Article
- Active Licking Shapes Cortical Taste Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery.Nutrients · 2022Article
- Neural Coding of Food Is a Multisensory, Sensorimotor Function.Nutrients · 2021Review
- Enhancing GABAergic Tone in the Rostral Nucleus of the Solitary Tract Reconfigures Sensorimotor Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Layer- and Cell Type-Specific Response Properties of Gustatory Cortex Neurons in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Optogenetic Stimulation of Type I GAD65The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
- Cortical processing of chemosensory and hedonic features of taste in active licking mice.Journal of neurophysiology · 2020Article
- Taste coding strategies in insular cortex.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.Chemical senses · 2019Review
- Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorderJournal of psychiatry & neuroscience : JPN · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
It is becoming increasingly clear that the brain processes sensory stimuli differently according to whether they are passively or actively acquired, and these differences can be seen early in the sensory pathway. In the nucleus of the solitary tract (NTS), the first relay in the central gustatory neuraxis, a rich variety of sensory inputs generated by active licking converge. Here, we show that taste responses in the NTS reflect these interactions. Experiments consisted of recordings of taste-related activity in the NTS of awake rats as they freely licked exemplars of the five basic taste qualities (sweet, sour, salty, bitter, umami). Nearly all taste-responsive cells were broadly tuned across taste qualities. A subset responded to taste with long latencies (>1.0 s), suggesting the activation of extraoral chemoreceptors. Analyses of the temporal characteristics of taste responses showed that spike timing conveyed significantly more information than spike count alone in almost one-half of NTS cells, as in anesthetized rats, but with less information per cell. In addition to taste-responsive cells, the NTS contains cells that synchronize with licks. Since the lick pattern per se can convey information, these cells may collaborate with taste-responsive cells to identify taste quality. Other cells become silent during licking. These latter "antilick" cells show a surge in firing rate predicting the beginning and signaling the end of a lick bout. Collectively, the data reveal a complex array of cell types in the NTS, only a portion of which include taste-responsive cells, which work together to acquire sensory information.
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