ArticleGenes & development2012
Identification of a DNA methylation-independent imprinting control region at the Arabidopsis MEDEA locus.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Allelic expression ofFrontiers in plant science · 2023Article
- Epigenetics Regulates Reproductive Development in Plants.Plants (Basel, Switzerland) · 2019Review
- Regulation of Parent-of-Origin Allelic Expression in the Endosperm.Plant physiology · 2019Article
- Differential Diel Translation of Transcripts With Roles in the Transfer and Utilization of Iron-Sulfur Clusters in Arabidopsis.Frontiers in plant science · 2018Article
- Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development.PLoS genetics · 2016Article
- Evolution and function of genomic imprinting in plants.Genes & development · 2015Review
- An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected].PLoS genetics · 2015Article
- Article
- The female gametophyte: an emerging model for cell type-specific systems biology in plant development.Frontiers in plant science · 2015Review
- Involvement of Iron-Containing Proteins in Genome Integrity in Arabidopsis Thaliana.Genome integrity · 2015Review
- Transcriptional silencing by polycomb-group proteins.Cold Spring Harbor perspectives in biology · 2014Review
- Epigenetic memory in plants.The EMBO journal · 2014Review
- Chromatin dynamics during plant sexual reproduction.Frontiers in plant science · 2014Review
- New insights into the functional roles of reactive oxygen species during embryo sac development and fertilization in Arabidopsis thaliana.Plant signaling & behavior · 2013Article
- Efficient and rapid isolation of early-stage embryos from Arabidopsis thaliana seeds.Journal of visualized experiments : JoVE · 2013Article
- Article
- Genomic imprinting in the Arabidopsis embryo is partly regulated by PRC2.PLoS genetics · 2013Article
- The Armadillo repeat gene ZAK IXIK promotes Arabidopsis early embryo and endosperm development through a distinctive gametophytic maternal effect.The Plant cell · 2012Article
- Reprogramming the epigenome in Arabidopsis pollen.Cold Spring Harbor symposia on quantitative biology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic imprinting is exclusive to mammals and seed plants and refers to parent-of-origin-dependent, differential transcription. As previously shown in mammals, studies in Arabidopsis have implicated DNA methylation as an important hallmark of imprinting. The current model suggests that maternally expressed imprinted genes, such as MEDEA (MEA), are activated by the DNA glycosylase DEMETER (DME), which removes DNA methylation established by the DNA methyltransferase MET1. We report the systematic functional dissection of the MEA cis-regulatory region, resulting in the identification of a 200-bp fragment that is necessary and sufficient to mediate MEA activation and imprinted expression, thus containing the imprinting control region (ICR). Notably, imprinted MEA expression mediated by this ICR is independent of DME and MET1, consistent with the lack of any significant DNA methylation in this region. This is the first example of an ICR without differential DNA methylation, suggesting that factors other than DME and MET1 are required for imprinting at the MEA locus.
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