ArticleFrontiers in neuroscience2012
Functional organization and adaptability of a decision-making network in aplysia.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Low-dimensional signatures of neuronal activity associated with long-term operant conditioning in Aplysia.Communications biology · 2025Article
- An in vitro analog of learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Convergent effects of neuropeptides on the feeding central pattern generator ofJournal of neurophysiology · 2022Article
- Using an invertebrate model to investigate the mechanisms of short-term memory deficits induced by food deprivation.Behavioural brain research · 2022Article
- Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- cGMP mediates short- and long-term modulation of excitability in a decision-making neuron in Aplysia.Neuroscience letters · 2018Article
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Long-term sensitization training inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2017Article
- A two-neuron system for adaptive goal-directed decision-making in Lymnaea.Nature communications · 2016Article
- Phylogenetic and individual variation in gastropod central pattern generators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Change in excitability of a putative decision-making neuron in Aplysia serves as a mechanism in the decision not to feed following food satiation.Behavioural brain research · 2015Article
- The significance of dynamical architecture for adaptive responses to mechanical loads during rhythmic behavior.Journal of computational neuroscience · 2015Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Aplysia Ganglia preparation for electrophysiological and molecular analyses of single neurons.Journal of visualized experiments : JoVE · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas major insights into the neuronal basis of adaptive behavior have been gained from the study of automatic behaviors, including reflexive and rhythmic motor acts, the neural substrates for goal-directed behaviors in which decision-making about action selection and initiation are crucial, remain poorly understood. However, the mollusk Aplysia is proving to be increasingly relevant to redressing this issue. The functional properties of the central circuits that govern this animal's goal-directed feeding behavior and particularly the neural processes underlying the selection and initiation of specific feeding actions are becoming understood. In addition to relying on the intrinsic operation of central networks, goal-directed behaviors depend on external sensory inputs that through associative learning are able to shape decision-making strategies. Here, we will review recent findings on the functional design of the central network that generates Aplysia's feeding-related movements and the sensory-derived plasticity that through learning can modify the selection and initiation of appropriate action. The animal's feeding behavior and the implications of decision-making will be briefly described. The functional design of the underlying buccal network will then be used to illustrate how cellular diversity and the coordination of neuronal burst activity provide substrates for decision-making. The contribution of specific synaptic and neuronal membrane properties within the buccal circuit will also be discussed in terms of their role in motor pattern selection and initiation. The ability of learning to "rigidify" these synaptic and cellular properties so as to regularize network operation and lead to the expression of stereotyped rhythmic behavior will then be described. Finally, these aspects will be drawn into a conceptual framework of how Aplysia's goal-directed circuitry compares to the central pattern generating networks for invertebrate rhythmic behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.