ReviewBlood2012
The murine allantois: a model system for the study of blood vessel formation.
Review in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Select Histochemical and Immunohistochemical Methods to Investigate the Cell and Tissue Composition of the Mouse Placenta and Metrial Gland.Toxicologic pathology · 2026Review
- Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis.iScience · 2026Article
- Dll4 assembles the umbilical cord and placental vasculature.JCI insight · 2026Article
- Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues.Developmental cell · 2025Article
- Regulation of placental development and function by ubiquitination.Molecular medicine (Cambridge, Mass.) · 2025Review
- Article
- Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems.Frontiers in physiology · 2024Review
- Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes.Developmental biology · 2023Article
- Embryonic and extraembryonic tissues during mammalian development: shifting boundaries in time and space.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.Developmental cell · 2022Article
- Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.The EMBO journal · 2022Article
- Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.Frontiers in genetics · 2021Article
- Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.International journal of molecular sciences · 2020Article
- Blood Flow Forces in Shaping the Vascular System: A Focus on Endothelial Cell Behavior.Frontiers in physiology · 2020Review
- Siva plays a critical role in mouse embryonic development.Cell death and differentiation · 2020Article
- Building and Regenerating the Lung Cell by Cell.Physiological reviews · 2019Review
- Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice.Molecular biology of the cell · 2018Article
- Consensus guidelines for the use and interpretation of angiogenesis assays.Angiogenesis · 2018Review
- Dissection and Explant Culture of Murine Allantois for the In Vitro Analysis of Allantoic Attachment.Journal of visualized experiments : JoVE · 2018Article
- Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The allantois is the embryonic precursor of the umbilical cord in mammals and is one of several embryonic regions, including the yolk sac and dorsal aorta, that undergoes vasculogenesis, the de novo formation of blood vessels. Despite its importance in establishing the chorioallantoic placenta and umbilical circulation, the allantois frequently is overlooked in embryologic studies. Nonetheless, recent studies demonstrate that vasculogenesis, vascular remodeling, and angiogenesis are essential allantois functions in the establishment of the chorioallantoic placenta. Here, we review blood vessel formation in the murine allantois, highlighting the expression of genes and involvement of pathways common to vasculogenesis or angiogenesis in other parts of the embryo. We discuss experimental techniques available for manipulation of the allantois that are unavailable for yolk sac or dorsal aorta, and review how this system has been used as a model system to discover new genes and mechanisms involved in vessel formation. Finally, we discuss the potential of the allantois as a model system to provide insights into disease and therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.