ArticleNucleic acids research2012
Analysis of the epigenetic status of telomeres by using ChIP-seq data.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton.PLoS genetics · 2025Article
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis.Nature plants · 2023Article
- Epigenetic nature of Arabidopsis thaliana telomeres.Plant physiology · 2023Article
- Genetic and Epigenetic Inheritance at Telomeres.Epigenomes · 2022Review
- A complex network of interactions governs DNA methylation at telomeric regions.Nucleic acids research · 2022Article
- Tidying-up the plant nuclear space: domains, functions, and dynamics.Journal of experimental botany · 2020Review
- The epigenetic regulation of centromeres and telomeres in plants and animals.Comparative cytogenetics · 2020Review
- Review
- Article
- Epigenetic aspects of telomeric chromatin in Arabidopsis thaliana.BMB reports · 2019Review
- Review
- Evolution of Polycomb-group function in the green lineage.F1000Research · 2019Review
- Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.Nature communications · 2018Article
- Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis.Plant molecular biology · 2018Article
- Epigenetic features of human telomeres.Nucleic acids research · 2018Article
- DDM1 guards against telomere truncation in Arabidopsis.Plant cell reports · 2018Article
- Article
- Characterization of the Polycomb-Group Mark H3K27me3 in Unicellular Algae.Frontiers in plant science · 2017Article
- The Arabidopsis hnRNP-Q Protein LIF2 and the PRC1 Subunit LHP1 Function in Concert to Regulate the Transcription of Stress-Responsive Genes.The Plant cell · 2016Article
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Authors and funding
3 authors.
Funding
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Abstract
The chromatin structure of eukaryotic telomeres plays an essential role in telomere functions. However, their study might be impaired by the presence of interstitial telomeric sequences (ITSs), which have a widespread distribution in different model systems. We have developed a simple approach to study the chromatin structure of Arabidopsis telomeres independently of ITSs by analyzing ChIP-seq data. This approach could be used to study the chromatin structure of telomeres in some other eukaryotes. The analysis of ChIP-seq experiments revealed that Arabidopsis telomeres have higher density of histone H3 than centromeres, which might reflects their short nucleosomal organization. These experiments also revealed that Arabidopsis telomeres have lower levels of heterochromatic marks than centromeres (H3K9(Me2) and H3K27(Me)), higher levels of some euchromatic marks (H3K4(Me2) and H3K9Ac) and similar or lower levels of other euchromatic marks (H3K4(Me3), H3K36(Me2), H3K36(Me3) and H3K18Ac). Interestingly, the ChIP-seq experiments also revealed that Arabidopsis telomeres exhibit high levels of H3K27(Me3), a repressive mark that associates with many euchromatic genes. The epigenetic profile of Arabidopsis telomeres is closely related to the previously defined chromatin state 2. This chromatin state is found in 23% of Arabidopsis genes, many of which are repressed or lowly expressed. At least, in part, this scenario is similar in rice.
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