Trial reportThe Journal of clinical endocrinology and metabolism2012
The effect of vitamin D on calcium absorption in older women.
Trial report in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary calcium intake and change in bone mineral density in older adults: a systematic review of longitudinal cohort studies.European journal of clinical nutrition · 2022Pooled it
- Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Trial
- Treatment of Vitamin D Insufficiency in Postmenopausal Women: A Randomized Clinical Trial.JAMA internal medicine · 2015Trial
- Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women.Menopause (New York, N.Y.) · 2014Trial
- Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial.The American journal of clinical nutrition · 2013Trial
- Joint association of milk intake and blood 25(OH)D levels with fracture risk in postmenopausal women: 20-year follow-up data from the Japanese Population-Based Osteoporosis cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Vitamin D-Do Diet Recommendations for Health Remain Strong?Current osteoporosis reports · 2024Review
- Effects of Coffee on Gut Microbiota and Bowel Functions in Health and Diseases: A Literature Review.Nutrients · 2024Review
- Reference range for 24-h urine calcium, calcium/creatinine ratio, and correlations with calcium absorption and serum vitamin D metabolites in normal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review.BioMed research international · 2020Review
- Review
- Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population.Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Dietary Vitamin D Intake for the Elderly Population: Update on the Recommended Dietary Allowance for Vitamin D.Endocrinology and metabolism clinics of North America · 2017Review
- Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk?Urolithiasis · 2017Article
- The role of vitamin D in maintaining bone health in older people.Therapeutic advances in musculoskeletal disease · 2017Review
- Skeletal and nonskeletal effects of vitamin D: is vitamin D a tonic for bone and other tissues?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- No vitamin D threshold for calcium absorption: why does this matter?The American journal of clinical nutrition · 2014Article
- Estrogen treatment does not reduce fractures?Menopause (New York, N.Y.) · 2014Article
- Vitamin D endocrine system and the intestine.BoneKEy reports · 2014Article
- Clinical practice. Calcium supplements and fracture prevention.The New England journal of medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
contextVitamin D is often recommended for use with calcium supplements to increase absorption. There are no systematic studies of vitamin D on calcium absorption that indicate what dose should be recommended.
objectiveOur objective was to study the effect of increasing doses of vitamin D3 on calcium absorption. DESIGN AND
settingWe conducted a randomized double-blind placebo-controlled trial at Creighton University Medical Center, Omaha, NE.
participantsParticipants included 163 postmenopausal Caucasian women with vitamin D insufficiency, defined as a serum 25-hydroxyvitamin D (25OHD) below 20 ng/ml (50 nmol/liter).
interventionParticipants were randomized to receive one of the vitamin D3 doses, 400, 800, 1600, 2400, 3200, 4000, or 4800 IU/d, or placebo for 1 yr. Calcium intake was increased to 1200-1400 mg daily by giving daily calcium citrate. MAIN OUTCOME: We evaluated the change in calcium absorption on vitamin D.
resultsMean serum 25OHD increased from baseline 15.6 ng/ml (39 nmol/liter) to 46.5 ng/ml (112 nmol/liter) in subjects randomized to the highest dose of vitamin D (4800 IU). Calcium absorption was more significantly related to serum 25OHD (R2=0.50; P=0.001) than dose (R2=0.47; P=0.033). Calcium absorption of a 100-mg dose increased from 52-58% (6 mg) over a serum 25OHD range of 20-66 ng/ml (50-165 nmol/liter).
conclusionsThere was no evidence of a threshold for reduced calcium absorption in the serum 25OHD range of 10-66 ng/ml (25-165 nmol/liter). The increase in absorbed calcium of 6% on high doses of vitamin D is so small that the same amount could be obtained from half a glass of milk (100 ml) or 100 mg elemental calcium. The results challenge assumptions about the value of adding vitamin D to increase calcium absorption except when serum 25OHD is very low that is less than 10 ng/ml (25 nmol/liter).
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