ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2012
Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Distant metastasis from oral cavity-correlation between histopathology results and primary site.Oral radiology · 2021Pooled it
- Prevalence of oral epithelial dysplasia and oral squamous cell carcinoma in Alexandria University Hospital in Egypt: a ten-year retrospective study.BMC oral health · 2026Article
- Nomograms for predicting prognosis in postoperative lip squamous cell carcinoma patients.Discover oncology · 2025Article
- Comprehensive survival analysis of oral squamous cell carcinoma patients undergoing initial radical surgery.BMC oral health · 2024Article
- Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single-center study on 10 years of cancer registry data.Oncology letters · 2022Article
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- Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China-a 10-year continuous single-center study.BMC oral health · 2020Article
- Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors.PloS one · 2020Article
- Changes in oncogenic protein levels in peri-implant oral malignancy: a case report.Maxillofacial plastic and reconstructive surgery · 2019Article
- A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study-Part 4 (Biomarkers).Frontiers in oncology · 2019Article
- KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.Oncotarget · 2017Article
- Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays.Oncology letters · 2016Article
- Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Estrogen and Progesterone hormone receptor expression in oral cavity cancer.Medicina oral, patologia oral y cirugia bucal · 2016Article
- A simple prognostic score system predicts the prognosis of solitary large hepatocellular carcinoma following hepatectomy.Medicine · 2016Article
- Evaluation of a biomarker based blood test for monitoring surgical resection of oral squamous cell carcinomas.Clinical oral investigations · 2016Article
- Glutaminolysis and carcinogenesis of oral squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma.Nanomaterials (Basel, Switzerland) · 2015Article
- Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC.Medicina oral, patologia oral y cirugia bucal · 2015Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral clinicopathological parameters have been implicated in prognosis, recurrence and survival, following oral squamous cell carcinoma (OSCC). The purpose of this retrospective study was to review the outcome of patients with oral cavity squamous cell carcinoma treated at a single institution by primary surgical resection with or without adjuvant radiotherapy or radiochemotherapy, or brachytherapy and to identify the factors affecting survival and locoregional control. MATERIALS AND
methodsWe retrospectively reviewed the records of 429 consecutive patients after primary radical R0 tumor resection and 55 patients after brachytherapy in our department between 1997 and 2010. OSCC pathological parameters were analyzed including age, gender, site distribution, tumor size, lymph node involvement, grading, microvascular invasion, lymphatic vessel involvement, and distant metastasis. Descriptive statistics were calculated for each variable and survival was calculated using the univariate Kaplan-Meier method. Prognostic factors were analyzed using the multivariate Cox proportional hazard model.
resultsAverage tumor size was 10.9 mm (95 % CI for the mean 9.6-12.3). Disease-free survival at 5 years was 65 % and overall 5-year survival was 62 %. On univariate analysis, patients with increased tumor size, lymph node involvement, microvascular invasion, and lymphatic vessel involvement had a significant poor prognosis. Multivariate analysis showed that independent prognostic factors were increased tumor size and microvascular invasion.
conclusionThis hospital-based retrospective cohort study points out different clinicopathological prognostic factors of survival in a large patient cohort treated for OSCC. It highlights increased tumor size and microvascular invasion as the most independent prognostic factors in predicting survival in patients with OSCC.
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