ArticleVirchows Archiv : an international journal of pathology2012
Cancer of unknown primary originating from oropharyngeal carcinomas are strongly correlated to HPV positivity.
Article in Virchows Archiv : an international journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review.Clinical & experimental metastasis · 2015Pooled it
- Transoral robotic approach to carcinoma of unknown primary.Head & neck · 2014Trial
- The Effectiveness of Tonsillectomy in the Diagnostic Workup of Squamous Cell Carcinoma Unknown Primary in the Head and Neck Based on p16 Immunohistochemistry.Medicina (Kaunas, Lithuania) · 2024Article
- Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study.Head and neck pathology · 2024Article
- Article
- Branchial cleft cyst and branchial cleft cyst carcinoma, or cystic lymph node and cystic nodal metastasis?The Journal of laryngology and otology · 2023Review
- Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report.Head & neck · 2022Article
- Awareness of HPV-associated oropharyngeal cancers among GPs in The Netherlands: a cross-sectional study.BJGP open · 2022Article
- Lymphoepithelial carcinoma of the parotid gland: a unique example showing p16 immunoreactivity.Medical molecular morphology · 2021Article
- Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients.BMC cancer · 2018Article
- [Morphology of non cutaneous head and neck squamous cell carcinoma].Der Pathologe · 2018Review
- The involvement of E6, p53, p16, MDM2 and Gal-3 in the clinical outcome of patients with cervical cancer.Oncology letters · 2017Article
- Prognostic Importance of Comorbidity and the Association Between Comorbidity and p16 in Oropharyngeal Squamous Cell Carcinoma.JAMA otolaryngology-- head & neck surgery · 2016Article
- Approach to metastatic carcinoma of unknown primary in the head and neck: squamous cell carcinoma and beyond.Head and neck pathology · 2015Review
- Head and neck squamous cell carcinoma of unknown primary: neck dissection and radiotherapy or definitive radiotherapy.Head & neck · 2014Article
- Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.Journal of cancer research and clinical oncology · 2014Article
- [The visionary concept of "lymphoepithelioma" by A. Schmincke in 1921. Subsequent confusion over terminology and current approach to a solution].Der Pathologe · 2014Article
- [HPV-associated oropharyngeal carcinoma. Status quo and relationship with cancer of unknown primary].Der Pathologe · 2014Review
- Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival.PloS one · 2014Article
- Detection of HPV infection in head and neck squamous cell carcinoma: a practical proposal.Virchows Archiv : an international journal of pathology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OSCC) has been identified as a distinct entity within squamous cell carcinoma of the head and neck. It is associated with special characteristics and is preponderantly restricted to palatial tonsils and base of tongue. These primary locations have for long been associated with the clinical situation of cancer of unknown primary (CUP). In order to investigate the putative relationship between CUP and HPV, we investigated 26 patients who initially presented as CUP and were finally diagnosed with carcinomas of these two locations. Twenty-one cases proved to be positive for high-risk HPV. Primary carcinomas were small and frequently presented in a submucosal location. HPV-positive carcinomas, presented more often in women, showed atypical basaloid differentiation and correlated to cystic lymph node metastases. This study demonstrates an over-representation of HPV-associated OSCC in patients who were initially diagnosed with CUP. This finding indicates a strong relationship between HPV-association and CUP in OSCC. The frequent manifestation as CUP is presumably caused by the unusual predisposition for small size and submucosal location combined with early lymphatic metastization. In order not to miss clinically occult carcinomas, consequent interdisciplinary cooperation in combination with meticulous histological workup is mandatory.
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