Evidence map›Paper›PMID 22854984›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2012

Prognostic value of pretreatment ¹⁸F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma.

Nai-Ming Cheng, Joseph Tung-Chieh Chang, Chung-Guei Huang, Din-Li Tsan, Shu-Hang Ng, Hung-Ming Wang, Chun-Ta Liao, Chien-Yu Lin, Cheng-Lung Hsu, Tzu-Chen Yen

Abstract readEvaluation Study
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
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  6. Article
  7. Influence of Semiquantitative [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  8. CT and FDG-PET radiologic biomarkers in p16+ oropharyngeal squamous cell carcinoma patients treated with definitive chemoradiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Article
  9. Article
  10. Article
  11. VolumetricHead & neck · 2019
    Article
  12. Article
  13. Radiomic Profiling of Head and Neck Cancer:Contrast media & molecular imaging · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. The role of PET/CT in the management of patients affected by head and neck tumors: a review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nai-Ming ChengDepartment of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
Joseph Tung-Chieh Chang
Chung-Guei Huang
Din-Li Tsan
Shu-Hang Ng
Hung-Ming Wang
Chun-Ta Liao
Chien-Yu Lin
Cheng-Lung Hsu
Tzu-Chen Yen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHuman papillomavirus type 16 (HPV-16) positivity is associated with favourable survival in oropharyngeal squamous cell carcinoma (OPSCC). We report here a study of the prognostic significance of (18)F-FDG PET/CT functional parameters and HPV-16 infection in OPSCC patients.

methodsWe retrospectively analysed 60 patients with stage III or IV OPSCC who had had a pretherapy (18)F-FDG PET/CT scan and had completed concurrent chemoradiotherapy (n = 58) or curative radiotherapy (n = 2). All patients were followed up for ≥24 months or until death. We determined total lesion glycolysis (TLG) and the maximal standardized uptake values (SUV(max)) of the primary tumour and neck lymph nodes from the pretherapy (18)F-FDG PET/CT scan. Optimal cut-offs of the (18)F-FDG PET/CT parameters were obtained by receiver operating characteristic (ROC) curve analyses. Pretherapy tumour biopsies were studied by polymerase chain reaction to determine HPV infection status.

resultsThe pretherapy tumour biopsies were positive for HPV-16 in 12 patients (20.0 %). Cox regression analyses revealed HPV-16 positivity and tumour TLG >135.3 g to be independently associated with overall survival (p = 0.027 and 0.011, respectively). However, only tumour TLG >135.3 g was independently associated with progression-free survival, disease-free survival and locoregional control (p = 0.011, 0.001 and 0.034, respectively). A scoring system was formulated to define distinct overall survival groups using tumour TLG and HPV-16 status. Patients positive for HPV-16 and with tumour TLG ≤135.3 g experienced better survival than those with tumour TLG >135.3 g and no HPV infection (p = 0.001).

conclusionTumour TLG was an independent predictor of survival in patients with locally advanced OPSCC. A scoring system was developed and may serve as a risk stratification strategy for guiding therapy.

Indexed as

Fluorodeoxyglucose F18Multimodal ImagingPositron-Emission TomographyRadiopharmaceuticalsTomography, X-Ray ComputedAdultAgedAged, 80 and overCarcinoma, Squamous CellFemaleHuman papillomavirus 16Human Papillomavirus DNA TestsHumansMaleMiddle AgedOropharyngeal NeoplasmsFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID22854984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.