Evidence map›Paper›PMID 22854878›Full record

SynthesisEuropean journal of clinical nutrition2012

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis.

A J Cooper, N G Forouhi, Z Ye, B Buijsse, L Arriola, B Balkau, A Barricarte, J W J Beulens, H Boeing, F L Büchner and 30 more

Open access · greenAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 21 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 21 syntheses or guidelines pooled it, 266 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 8 countries.

A J CooperMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
N G Forouhi
Z Ye
B Buijsse
L Arriola
B Balkau
A Barricarte
J W J Beulens
H Boeing
F L Büchner
C C Dahm
B de Lauzon-Guillain
G Fagherazzi
P W Franks
C Gonzalez
S Grioni
R Kaaks
T J Key
G Masala
C Navarro
P Nilsson
K Overvad
S Panico
J Ramón Quirós
O Rolandsson
N Roswall
C Sacerdote
M-J Sánchez
N Slimani
I Sluijs
A M W Spijkerman
B Teucher
A Tjonneland
R Tumino
S J Sharp
C Langenberg
E J M Feskens
E Riboli
N J Wareham
InterAct Consortium
MRC Epidemiology Unit · GBAalborg University Hospital · DKCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESDanish Cancer Society · DKGerman Institute of Human Nutrition · DENational Institute for Public Health and the Environment · NLPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUniversité Paris-Sud · FRUniversity Medical Center Utrecht · NLAddenbrooke's Hospital · GBAzienda Usl 8 Arezzo · ITBasque Government · ESCentre International de Recherche sur le Cancer · FRFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Cancer Research Center · DEHeidelberg University · DEHospital de l'Esperança · ESInserm · FRMalmö University · SE

Funding

Cancer Research UKMedical Research Council MC_U106179471Medical Research Council MC_UP_A100_1003
6 · The paper itself

Abstract

Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16,154 participants and 12,403 incident cases of T2D were identified from 340,234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.

Indexed as

FruitVegetablesDiabetes Mellitus, Type 2DietEuropeEvidence-Based MedicineHumansIncidencePlant LeavesPlant RootsPrevalenceRisk

Identifiers

PMID22854878
PMCPMC3652306
OpenAlexW2014838352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.