Evidence map›Paper›PMID 22854787›Full record

ArticleChemical communications (Cambridge, England)2012

Chemoenzymatic synthesis of cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside: a product of host cholesterol efflux promoted by Helicobacter pylori.

Ryan A Davis, Chun-Hung Lin, Jacquelyn Gervay-Hague

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. AnomericMolecules (Basel, Switzerland) · 2018
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ryan A DavisDepartment of Chemistry, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Chun-Hung Lin
Jacquelyn Gervay-Hague
University of California, Davis · USInstitute of Biological Chemistry, Academia Sinica · TW

Funding

Synthesis and Screening of Bioactive GlycolipidsR01GM090262 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERVAY-HAGUE, JACQUELYN · 2009 to 2012
$1.2M
NIGMS NIH HHS R01 GM090262NIGMS NIH HHS R01GM090262OCPHP CDC HHS PR1973
6 · The paper itself

Abstract

In a three-step protocol involving regioselective enzymatic acylation, per-O-trimethylsilylation, and a one-pot α-glycosidation-deprotection sequence, cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside (α-CAG) of Helicobacter pylori is afforded starting from glucose in an overall yield of 45%. The production of CAG can be scaled to make purified quantities available to the biological community for the first time.

Indexed as

Biological TransportChemistry Techniques, SyntheticCholesterolFungal ProteinsGlycolipidsHelicobacter pyloriLipaseSaponinsStereoisomerismSubstrate SpecificityCholesterolcholesteryl glucosideFungal ProteinsGlycolipidsLipaselipase B, Candida antarcticaSaponins

Identifiers

PMID22854787
PMCPMC4271795
OpenAlexW2009018968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.