ArticleThe American journal of clinical nutrition2012
Dietary fat quality and risk of sudden cardiac death in women.
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Pooled it
- Dietary Intake and Biomarkers of α-Linolenic Acid and Mortality: A Meta-Analysis of Prospective Cohort Studies.Frontiers in nutrition · 2021Pooled it
- Fish Consumption and Coronary Heart Disease: A Meta-Analysis.Nutrients · 2020Pooled it
- Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies.Lipids in health and disease · 2019Pooled it
- Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association.Circulation · 2018Guideline
- Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies.Lipids in health and disease · 2014Pooled it
- Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis.BMJ (Clinical research ed.) · 2013Pooled it
- Plasma concentrations of trans fatty acids in persons with type 2 diabetes between September 2002 and April 2004.The American journal of clinical nutrition · 2013Trial
- Changes in fatty acid intake and subsequent risk of all-cause and cause-specific mortality in males and females: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Eicosapentaenoic Acid Rescues Cav1.2-L-Type CaInternational journal of molecular sciences · 2024Article
- Article
- Dietary Reference Intake of n-3 polyunsaturated fatty acids for Koreans.Nutrition research and practice · 2022Review
- The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet.Scientific reports · 2021Article
- Review
- The Assessment of Changes in the Fatty Acid Profile and Dietary Indicators Depending on the Storage Conditions of Goose Meat.Molecules (Basel, Switzerland) · 2021Article
- Mediterranean Diet Score, Dietary Patterns, and Risk of Sudden Cardiac Death in the REGARDS Study.Journal of the American Heart Association · 2021Article
- Habitual Fish Consumption, n-3 Fatty Acids, and Nuclear Magnetic Resonance Lipoprotein Subfractions in Women.Journal of the American Heart Association · 2020Article
- Article
- Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).Circulation. Arrhythmia and electrophysiology · 2019Article
- Fat Quality Index and Risk of Cardiovascular Disease in the Sun Project.The journal of nutrition, health & aging · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDietary n-3 PUFAs are inversely associated with risk of sudden cardiac death (SCD); however, little is known about other fats and SCD. Furthermore, concerns have been raised that high n-6 PUFA intake may attenuate the benefits of n-3 PUFAs.
objectiveWe examined associations and selected interactions between dietary fatty acids, expressed as a proportion of total fat and SCD.
designWe conducted a prospective cohort study among 91,981 women aged 34-59 y from the Nurses' Health Study in 1980. Over 30 y, we documented 385 SCDs.
resultsIn multivariable models, women in the highest compared with the lowest quintile of SFA intake had an RR of SCD of 1.44 (95% CI: 1.04, 1.98). Conversely, women in the highest compared with the lowest quintile of PUFA intake had an RR of SCD of 0.57 (95% CI: 0.41, 0.78). Intakes of n-6 and n-3 PUFAs were both significantly associated with a lower risk of SCD, and n-6 PUFAs did not modify the association between n-3 PUFAs and SCD. MUFAs and trans fats were not associated with SCD risk. After further adjustment for coronary heart disease (CHD) and CHD risk factors potentially in the causal pathway, the association between PUFAs and SCD remained significant, whereas the association for SFAs was no longer significant.
conclusionsIntake of PUFAs as a proportion of fat was inversely associated with SCD risk, independent of traditional CHD risk factors. These results support dietary guidelines to improve dietary fat quality by replacing intake of SFAs with n-6 and n-3 PUFAs.
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Registered trials
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