ArticleBehavioural pharmacology2012
Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats.
Article in Behavioural pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Differential exposure to palatable food and its effects on binge-like eating behavior in adolescent rats.Frontiers in psychology · 2024Article
- Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype.Frontiers in behavioral neuroscience · 2023Review
- Withdrawal: A key consideration in evaluating whether highly processed foods are addictive.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.Nutrients · 2022Review
- Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats.Neuropharmacology · 2022Article
- From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats.Addiction biology · 2022Article
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Patterned Feeding of a Hyper-Palatable Food (Oreo Cookies) Reduces Alcohol Drinking in Rats.Frontiers in behavioral neuroscience · 2021Article
- Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.Frontiers in neuroscience · 2021Article
- Article
- Reward sensitivity deficits in a rat model of compulsive eating behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Pattern of access to cafeteria-style diet determines fat mass and degree of spatial memory impairments in rats.Scientific reports · 2019Article
- Article
- Neuropharmacology of compulsive eating.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Review
- Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey.Psychopharmacology · 2018Article
- "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats".Psychopharmacology · 2017Article
- Pathological Overeating: Emerging Evidence for a Compulsivity Construct.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Palatable Hyper-Caloric Foods Impact on Neuronal Plasticity.Frontiers in behavioral neuroscience · 2017Review
- Neuroscience of Compulsive Eating Behavior.Frontiers in neuroscience · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The increased availability of highly palatable foods is a major contributing factor toward the development of compulsive eating in obesity and eating disorders. It has been proposed that compulsive eating may develop as a form of self-medication to alleviate the negative emotional state associated with withdrawal from highly palatable foods. This study was aimed at determining whether withdrawal from chronic, intermittent access to a highly palatable food was responsible for the emergence of depressive-like behavior. For this purpose, a group of male Wistar rats was provided a regular chow diet 7 days a week (Chow/Chow), whereas a second group of rats was provided chow for 5 days a week, followed by a 2-day access to a highly palatable sucrose diet (Chow/Palatable). Following 7 weeks of diet alternation, depressive-like behavior was assessed during withdrawal from the highly palatable diet and following renewed access to it, using the forced swim test, the sucrose consumption test, and the intracranial self-stimulation threshold procedure. It was found that Chow/Palatable rats withdrawn from the highly palatable diet showed increased immobility time in the forced swim test and decreased sucrose intake in the sucrose consumption test compared with the control Chow/Chow rats. Interestingly, the increased immobility in the forced swim test was abolished by renewing access to the highly palatable diet. No changes were observed in the intracranial self-stimulation threshold procedure. These results validate the hypothesis that withdrawal from highly palatable food is responsible for the emergence of depressive-like behavior, and they also show that compulsive eating relieves the withdrawal-induced negative emotional state.
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