ArticleClinical immunology (Orlando, Fla.)2012
Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase.
Article in Clinical immunology (Orlando, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Critical Overview of Molecular Insights into Osteoarthritis and Therapeutic Targets: Cytokines, RANKL, MMPs, Adipokines and Phosphate Dysregulation.International journal of molecular sciences · 2026Review
- Similarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β.Journal of orthopaedic surgery and research · 2022Article
- Effects of GH/IGF axis on bone and cartilage.Molecular and cellular endocrinology · 2021Review
- Activation of the NLRP3 Inflammasome by Particles from the Echinococcus granulosus Laminated Layer.Infection and immunity · 2020Article
- Calcium crystal deposition diseases - beyond gout.Nature reviews. Rheumatology · 2018Review
- Calcium-Containing Crystals and Osteoarthritis: an Unhealthy Alliance.Current rheumatology reports · 2018Review
- Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.Journal of molecular and cellular cardiology · 2018Article
- Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.Frontiers in immunology · 2018Review
- Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy.Frontiers in cellular neuroscience · 2018Review
- Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.Arthritis research & therapy · 2017Article
- The danger from within: alarmins in arthritis.Nature reviews. Rheumatology · 2016Review
- Simvastatin Effect on Calcium and Silicon Plasma Levels in Postmenopausal Women with Osteoarthritis.Biological trace element research · 2016Observational
- BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.Oncotarget · 2016Article
- Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis.PloS one · 2016Article
- Protective effects of Tougu Xiaotong capsule on tumor necrosis factor-α-injured UMR-106 cells.Experimental and therapeutic medicine · 2015Article
- Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.Nature communications · 2015Article
- Osteoarthritis year in review 2013: biology.Osteoarthritis and cartilage · 2013Review
- Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations.Therapeutic advances in musculoskeletal disease · 2013Article
- Article
- Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.PLoS pathogens · 2013Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pro-inflammatory cytokines, TNFα, IL-1 and IL-18, amplify cartilage destruction associated with osteoarthritis (OA). Current data suggest that basic calcium phosphate (BCP) crystals are potent drivers of inflammatory mediator and matrix metalloprotease expression in the OA joint. It has previously been demonstrated that synovial macrophages play a role in initiating and driving BCP-induced inflammation. However, the molecular mechanisms by which BCP crystals exert their effects remain unclear. Here we demonstrate that exposure of macrophages to BCP crystals leads to activation of Syk and PI3 kinase. Furthermore, we show that production of pro-inflammatory cytokines and phosphorylation of the downstream kinase, ERK, are suppressed following treatment with Syk and PI3 kinase inhibitors. Finally, we demonstrate that treatment of macrophages with BCP crystals induces the production of the damage-associated molecule, S100A8, in a Syk dependent manner. We therefore identify Syk and PI3 kinase as potential novel targets for the treatment of BCP-related pathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.