ArticleCell reports2012
Convergent evolution of sodium ion selectivity in metazoan neuronal signaling.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder.Molecular brain · 2026Article
- The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.Nature reviews. Neuroscience · 2026Review
- Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution.Nature communications · 2025Article
- A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system.Development (Cambridge, England) · 2025Article
- Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor.Communications biology · 2025Article
- Normal locomotion in zebrafish lacking the sodium channel NaV1.4 suggests that the need for muscle action potentials is not universal.PLoS biology · 2025Article
- Dynamics of neural activity in early nervous system evolution.Current opinion in behavioral sciences · 2024Article
- Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels.The Journal of general physiology · 2024Article
- Electrophysiology of Ctenophore Smooth Muscle.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Genome-Scale Analysis Reveals Extensive Diversification of Voltage-Gated K+ Channels in Stem Cnidarians.Genome biology and evolution · 2023Article
- Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.Human molecular genetics · 2022Article
- Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells.Channels (Austin, Tex.) · 2021Article
- The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels.Biophysics and physicobiology · 2021Article
- A Novel Single-Domain NaPlant physiology · 2020Article
- Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemoneThe Journal of experimental biology · 2020Article
- A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence.eLife · 2020Article
- Characterization of nAChRs inEvoDevo · 2019Article
- Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone.BMC biology · 2018Article
- Diversity and evolution of four-domain voltage-gated cation channels of eukaryotes and their ancestral functional determinants.Scientific reports · 2018Article
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7 authors.
Funding
Abstract
Ion selectivity of metazoan voltage-gated Na(+) channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca(2+) ions, the expression and characterization of Na(+) channel homologs from the sea anemone Nematostella vectensis, a member of the early-branching metazoan phylum Cnidaria, revealed a sodium-selective channel bearing a noncanonical SF. Mutagenesis and physiological assays suggest that pore elements additional to the SF determine the preference for Na(+) in this channel. Phylogenetic analysis assigns the Nematostella Na(+)-selective channel to a channel group unique to Cnidaria, which diverged >540 million years ago from Ca(2+)-conducting Na(+) channel homologs. The identification of Cnidarian Na(+)-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na(+) in neuronal signaling emerged independently in these two animal lineages.
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