ArticleBiophysical journal2012
E-cadherin-dependent stimulation of traction force at focal adhesions via the Src and PI3K signaling pathways.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration.Developmental cell · 2023Article
- Deep-learning-based 3D cellular force reconstruction directly from volumetric images.Biophysical journal · 2022Article
- Local contractions regulate E-cadherin rigidity sensing.Science advances · 2022Article
- Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation.Frontiers in cell and developmental biology · 2022Article
- Article
- Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4'-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells.Frontiers in neuroscience · 2021Article
- Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces.International journal of molecular sciences · 2019Article
- Spontaneous migration of cellular aggregates from giant keratocytes to running spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cooperative Contraction Behaviors of a One-Dimensional Cell Chain.Biophysical journal · 2018Article
- Progress in Integrative Biomaterial Systems to Approach Three-Dimensional Cell Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- Vinculin in cell-cell and cell-matrix adhesions.Cellular and molecular life sciences : CMLS · 2017Review
- Biophysical Tools to Study Cellular Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry.Scientific reports · 2016Article
- Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates.Molecular biology of the cell · 2016Article
- Mechanotransduction of Neural Cells Through Cell-Substrate Interactions.Tissue engineering. Part B, Reviews · 2016Review
- E-cadherin-mediated force transduction signals regulate global cell mechanics.Journal of cell science · 2016Article
- Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling.Molecular medicine reports · 2016Article
- P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.The Journal of cell biology · 2016Article
- Advancing Edge Speeds of Epithelial Monolayers Depend on Their Initial Confining Geometry.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between cadherin- and integrin-dependent signals controls cell behavior, but the precise mechanisms that regulate the strength of adhesion to the extracellular matrix remains poorly understood. We deposited cells expressing a defined repertoire of cadherins and integrins on fibronectin (FN)-coated polyacrylamide gels (FN-PAG) and on FN-coated pillars used as a micro-force sensor array (μFSA), and analyzed the functional relationship between these adhesion receptors to determine how it regulates cell traction force. We found that cadherin-mediated adhesion stimulated cell spreading on FN-PAG, and this was modulated by the substrate stiffness. We compared S180 cells with cells stably expressing different cadherins on μFSA and found that traction forces were stronger in cells expressing cadherins than in parental cells. E-cadherin-mediated contact and mechanical coupling between cells are required for this increase in cell-FN traction force, which was not observed in isolated cells, and required Src and PI3K activities. Traction forces were stronger in cells expressing type I cadherins than in cells expressing type II cadherins, which correlates with our previous observation of a higher intercellular adhesion strength developed by type I compared with type II cadherins. Our results reveal one of the mechanisms whereby molecular cross talk between cadherins and integrins upregulates traction forces at cell-FN adhesion sites, and thus provide additional insight into the molecular control of cell behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.