ReviewNutrition research reviews2012
Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?
Review in Nutrition research reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Mindfulness-Based Stress Reduction on breast cancer symptoms: systematic review and meta-analysis.Einstein (Sao Paulo, Brazil) · 2018Pooled it
- Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association.Circulation · 2018Pooled it
- The Complex Path from Mammary Ductal Hyperplasia to Breast Cancer: Elevated Malignancy Risk in Atypical Forms.Biomedicines · 2026Review
- Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights.Cell biology and toxicology · 2025Review
- Stress reduction strategies in breast cancer: review of pharmacologic and non-pharmacologic based strategies.Seminars in immunopathology · 2020Review
- Editorial: Perspectives in Primary Prevention Research for Breast Cancer: A Focus on Gene-Environment Interactions.Frontiers in medicine · 2020Article
- Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study.Clinical epigenetics · 2019Article
- Baicalin Inhibits Cell Viability, Migration and Invasion in Breast Cancer by Regulating miR-338-3p and MORC4.OncoTargets and therapy · 2019Article
- Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk.Endocrine-related cancer · 2017Article
- A high-fat diet increases the incidence of mammary cancer inc-Ha-Journal of toxicologic pathology · 2017Article
- The Role of Oral Contraceptive Pills on Increased Risk of Breast Cancer in Iranian Populations: A Meta-analysis.Journal of cancer prevention · 2016Article
- Review
- Article
- Lifestyle, nutrition and breast cancer: facts and presumptions for consideration.Ecancermedicalscience · 2015Review
- The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus and the importance of sexual dimorphism and body region.Proceedings. Biological sciences · 2014Article
- Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats.The Journal of nutritional biochemistry · 2014Article
- Taking a chance on epigenetics.Frontiers in genetics · 2014Article
- Global nutrition research: nutrition and breast cancer prevention as a model.Nutrition reviews · 2013Review
- Building risk-on-a-chip models to improve breast cancer risk assessment and prevention.Integrative biology : quantitative biosciences from nano to macro · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Breast cancer incidence is rising worldwide with an increase in aggressive neoplasias in young women. Possible factors involved include lifestyle changes, notably diet that is known to make an impact on gene transcription. However, among dietary factors, there is sufficient support for only greater body weight and alcohol consumption whereas numerous studies revealing an impact of specific diets and nutrients on breast cancer risk show conflicting results. Also, little information is available from middle- and low-income countries. The diversity of gene expression profiles found in breast cancers indicates that transcription control is critical for the outcome of the disease. This suggests the need for studies on nutrients that affect epigenetic mechanisms of transcription, such as DNA methylation and post-translational modifications of histones. In the present review, a new examination of the relationship between diet and breast cancer based on transcription control is proposed in light of epidemiological, animal and clinical studies. The mechanisms underlying the impact of diets on breast cancer development and factors that impede reaching clear conclusions are discussed. Understanding the interaction between nutrition and epigenetics (gene expression control via chromatin structure) is critical in light of the influence of diet during early stages of mammary gland development on breast cancer risk, suggesting a persistent effect on gene expression as shown by the influence of certain nutrients on DNA methylation. Successful development of breast cancer prevention strategies will require appropriate models, identification of biological markers for rapid assessment of preventive interventions, and coordinated worldwide research to discern the effects of diet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.