Evidence map›Paper›PMID 22853708›Full record

ArticleACS combinatorial science2012

Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

Qin Zang, Salim Javed, David Hill, Farman Ullah, Danse Bi, Patrick Porubsky, Benjamin Neuenswander, Gerald H Lushington, Conrad Santini, Michael G Organ and 1 more

Abstract readLetter
In one paragraph

Article in ACS combinatorial science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Machine-Assisted Organic Synthesis.Angewandte Chemie (International ed. in English) · 2015
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qin Zang
Salim Javed
David Hill
Farman Ullah
Danse Bi
Patrick Porubsky
Benjamin Neuenswander
Gerald H Lushington
Conrad Santini
Michael G Organ
Paul R Hanson

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ACKLEY, BRIAN DOUGLAS · 2001 to 2011
$38.1M
Phase trafficking in combinatorial chemistry: ROM polymerizationP50GM069663 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AUBE, JEFFREY · 2003 to 2012
$18.9M
Probing Diversity Space with Novel Pilot Scale LibrariesP41GM076302 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANSON, PAUL R. · 2005 to 2010
$2.6M
NCRR NIH HHS P20 RR016475NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P41 GM076302NIGMS NIH HHS P41-GM076302NIGMS NIH HHS P50 GM069663NIGMS NIH HHS P50-GM069663
6 · The paper itself

Abstract

The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

Indexed as

Combinatorial Chemistry TechniquesAutomationAza CompoundsAzepinesMolecular StructureSmall Molecule LibrariesSulfur1,4-diazepaneAza CompoundsAzepinesSmall Molecule LibrariesSulfur

Identifiers

PMID22853708
PMCPMC3656823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.