Evidence map›Paper›PMID 22851801›Full record

GuidelineSleep2012

The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.

R Nisha Aurora, David A Kristo, Sabin R Bista, James A Rowley, Rochelle S Zak, Kenneth R Casey, Carin I Lamm, Sharon L Tracy, Richard S Rosenberg, American Academy of Sleep Medicine

Open access · bronzeAbstract readMeta-AnalysisPractice GuidelineSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 14 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 14 syntheses or guidelines pooled it, 302 citations in OpenAlex.

  1. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Pooled it
  2. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Guideline
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  7. Migraine and sleep disorders: a systematic review.The journal of headache and pain · 2020
    Pooled it
  8. Iron for the treatment of restless legs syndrome.The Cochrane database of systematic reviews · 2019
    Pooled it
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  11. Opioids for restless legs syndrome.The Cochrane database of systematic reviews · 2016
    Pooled it
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

R Nisha AuroraJohns Hopkins University, School of Medicine, Baltimore, MD, USA.
David A Kristo
Sabin R Bista
James A Rowley
Rochelle S Zak
Kenneth R Casey
Carin I Lamm
Sharon L Tracy
Richard S Rosenberg
American Academy of Sleep Medicine
American Academy of Sleep Medicine · USColumbia University · USJohns Hopkins University · USSleepMed · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a STANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS.

Indexed as

Evidence-Based MedicineSleep Medicine SpecialtyAcademies and InstitutesBenzothiazolesCabergolineCarbamatesDopamine AgentsErgolinesgamma-Aminobutyric AcidHumansIndolesLevodopaNocturnal Myoclonus SyndromePergolidePeripheral Nervous System DiseasesPramipexole1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acidBenzothiazolesCabergolineCarbamatesDopamine AgentsErgolinesgamma-Aminobutyric AcidIndolesLevodopaPergolidePramipexoleropiniroleperiodic limb movement disorderPLMDRestless legs syndromeRLSsleep-related movement disorders

Identifiers

PMID22851801
PMCPMC3397811
OpenAlexW222867287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.