Update to the AASM Clinical Practice Guideline: "The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses".

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 327 citations in OpenAlex.

1. Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Benefits.Journal of general internal medicine · 2025
   Guideline
2. Polysomnographic features of idiopathic restless legs syndrome: a systematic review and meta-analysis of 13 sleep parameters and 23 leg movement parameters.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
   Pooled it
3. Benzodiazepines for restless legs syndrome.The Cochrane database of systematic reviews · 2017
   Pooled it
4. Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review.Psychopharmacology bulletin · 2025
   Article
5. Risk of Suicidal Ideation and Behavior Following Early-Onset Idiopathic Restless Legs Syndrome Treatment.Pharmacoepidemiology and drug safety · 2024
   Article
6. Potential Effect of Vortioxetine on Restless Leg Syndrome.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
   Article
7. A Randomized, Open Label, Exploratory Trial Comparing Efficacy of Amantadine and Ropinirole in Restless Legs Syndrome.Sleep science (Sao Paulo, Brazil) · 2023
   Article
8. Treatment initiation and utilization patterns of pharmacotherapies for early-onset idiopathic restless legs syndrome.Sleep medicine · 2022
   Article
9. Clonidine is better than zopiclone for insomnia treatment in chronic pain patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
   Observational
10. Low Arousal Threshold: A Potential Bridge Between OSA and Periodic Limb Movements of Sleep.Nature and science of sleep · 2021
    Article
11. Restless legs syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
    Article
12. Gabapentin Enacarbil: A Review in Restless Legs Syndrome.Drugs · 2016
    Review
13. Restless legs syndrome-current therapies and management of augmentation.Nature reviews. Neurology · 2015
    Review
14. Approach to insomnia in patients with dementia.Neurology. Clinical practice · 2014
    Article
15. Cardiovascular risk associated with co-morbid insomnia and sleep apnoea (COMISA) in type 2 diabetics.Sleep science (Sao Paulo, Brazil)
    Article
16. Orofacial-cervical alterations in individuals with upper airway resistance syndrome.Brazilian journal of otorhinolaryngology
    Article

Corrections and comments

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  The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.2012

Authors and funding

9 authors at 8 institutions in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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