ArticleHypertension (Dallas, Tex. : 1979)2012
Direct recording of renal sympathetic nerve activity in unrestrained, conscious mice.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise.Cardiovascular drugs and therapy · 2021Article
- Activation of the Sympathetic Nervous System Promotes Blood Pressure Salt-Sensitivity in C57BL6/J Mice.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner.Frontiers in pharmacology · 2020Article
- Upregulating Nrf2 in the RVLM ameliorates sympatho-excitation in mice with chronic heart failure.Free radical biology & medicine · 2019Article
- Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension.The Journal of physiology · 2019Article
- Stretchable Low Impedance Electrodes for Bioelectronic Recording from Small Peripheral Nerves.Scientific reports · 2019Article
- Modulation of renal sympathetic innervation: recent insights beyond blood pressure control.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.Journal of visualized experiments : JoVE · 2018Article
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.Nature communications · 2016Article
- Current Approaches to Quantifying Tonic and Reflex Autonomic Outflows Controlling Cardiovascular Function in Humans and Experimental Animals.Current hypertension reports · 2015Review
- Effects of leptin on sympathetic nerve activity in conscious mice.Physiological reports · 2015Article
- Recording sympathetic nerve activity chronically in rats: surgery techniques, assessment of nerve activity, and quantification.American journal of physiology. Heart and circulatory physiology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Renal sympathetic nerve activity (RSNA) has been measured in anesthetized mice. However, anesthesia and acute surgical preparation cause poor cardiovascular stability and unphysiological blood pressures. This compromised physiological state confounds proper interpretation of experimental results considering the inseparable link between cardiovascular status and autonomic nervous tone. We, therefore, developed a surgical and experimental protocol for measuring RSNA in conscious, unrestrained mice. Male C57Bl/6J mice were chronically instrumented with blood pressure radiotelemeters, an indwelling jugular venous catheter and a bipolar electrode for recording RSNA. Mice were placed in a home cage and left to recover for 48 to 72 hours. Survival rate was 100%; all of the mice exhibited normal behavior with no sign of distress 24 hours after surgery. RSNA was successfully recorded in 80% of the mice at 48 and 72 hours postsurgery; viable RSNA was reduced to 70% and 50% at 4 and 5 days postsurgery, respectively. Mean arterial pressure (116±2 mm Hg; n=10) was consistent with values reported previously for conscious mice. RSNA increased with the normal physical activities of eating and grooming and was validated by ganglionic blockade and pharmacological manipulation of blood pressure; reduction in blood pressure to 62±3 mm Hg with nitroprusside increased RSNA by 77±9% above baseline (n=5; P<0.05), whereas an increase in blood pressure to 137±6 mm Hg with phenylephrine reduced RSNA by 79±2% compared with baseline (n=5; P<0.05). Thus, we demonstrate an accessible and effective method for direct assessment of RSNA in conscious, unrestrained mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.