Evidence map›Paper›PMID 22851650›Full record

ArticleGenetics2012

A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae.

Pinar B Demirel, Brice E Keyes, Mandovi Chaterjee, Courtney E Remington, Daniel J Burke

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface.Frontiers in cell and developmental biology · 2020
    Review
  9. Article
  10. Tension sensors reveal how the kinetochore shares its load.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pinar B DemirelDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22906, USA.
Brice E Keyes
Mandovi Chaterjee
Courtney E Remington
Daniel J Burke
University of Virginia · USRockefeller University · US

Funding

Mitotic regulation by checkpoints in budding yeastR01GM086502 · NIGMS · UNIVERSITY OF VIRGINIA · PI BURKE, DANIEL J · 2009 to 2012
$1.4M
NIGMS NIH HHS GM086502NIGMS NIH HHS R01 GM086502
6 · The paper itself

Abstract

The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating a redundant function for the Ndc80 and Dam1 complexes in vivo.

Indexed as

Cell Cycle ProteinsMicrotubule-Associated ProteinsNuclear ProteinsSaccharomyces cerevisiae ProteinsChromosome SegregationKinetochoresMicrotubulesMitosisPhenotypeProtein BindingSaccharomyces cerevisiaeCell Cycle ProteinsDAM1 protein, S cerevisiaeMicrotubule-Associated ProteinsNDC80 protein, S cerevisiaeNuclear ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID22851650
PMCPMC3454895
OpenAlexW2155385930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.