ArticleGenome biology and evolution2012
An independent genome duplication inferred from Hox paralogs in the American paddlefish--a representative basal ray-finned fish and important comparative reference.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Chromosomal Replication, Translocation and Recombination as Putative Events in the Diversification of VertebrateInternational journal of molecular sciences · 2026Article
- A Class of Allopolyploidy Showing High Duplicate Retention and Continued Homoeologous Exchanges.Genome biology and evolution · 2025Article
- Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories.Genomics, proteomics & bioinformatics · 2024Article
- Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor.Nature communications · 2023Article
- Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs.Molecular biology and evolution · 2023Article
- Examination of white blood cell indicators for three different ploidy level sturgeon species reared in an indoor recirculation aquaculture system for one year.Veterinarni medicina · 2022Article
- The American Paddlefish Genome Provides Novel Insights into Chromosomal Evolution and Bone Mineralization in Early Vertebrates.Molecular biology and evolution · 2021Article
- Chromosome Distribution of Highly Conserved Tandemly Arranged Repetitive DNAs in the Siberian Sturgeon (Genes · 2020Article
- The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization.Nature ecology & evolution · 2020Article
- The gene-rich genome of the scallop Pecten maximus.GigaScience · 2020Article
- Article
- Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequence.Scientific reports · 2019Article
- Draft Genome and CompleteFrontiers in genetics · 2019Article
- Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates.BioMed research international · 2018Article
- Expression ofEvoDevo · 2018Article
- Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification.Genome biology · 2017Article
- Causes and evolutionary consequences of primordial germ-cell specification mode in metazoans.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Molecular cytogenetic differentiation of paralogs of Hox paralogs in duplicated and re-diploidized genome of the North American paddlefish (Polyodon spathula).BMC genetics · 2017Article
- The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.Nature genetics · 2016Article
- HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution.Scientific reports · 2016Article
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5 authors.
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Abstract
Vertebrates have experienced two rounds of whole-genome duplication (WGD) in the stem lineages of deep nodes within the group and a subsequent duplication event in the stem lineage of the teleosts-a highly diverse group of ray-finned fishes. Here, we present the first full Hox gene sequences for any member of the Acipenseriformes, the American paddlefish, and confirm that an independent WGD occurred in the paddlefish lineage, approximately 42 Ma based on sequences spanning the entire HoxA cluster and eight genes on the HoxD gene cluster. These clusters comprise different HOX loci and maintain conserved synteny relative to bichir, zebrafish, stickleback, and pufferfish, as well as human, mouse, and chick. We also provide a gene genealogy for the duplicated fzd8 gene in paddlefish and present evidence for the first Hox14 gene in any ray-finned fish. Taken together, these data demonstrate that the American paddlefish has an independently duplicated genome. Substitution patterns of the "alpha" paralogs on both the HoxA and HoxD gene clusters suggest transcriptional inactivation consistent with functional diploidization. Further, there are similarities in the pattern of sequence divergence among duplicated Hox genes in paddlefish and teleost lineages, even though they occurred independently approximately 200 Myr apart. We highlight implications on comparative analyses in the study of the "fin-limb transition" as well as gene and genome duplication in bony fishes, which includes all ray-finned fishes as well as the lobe-finned fishes and tetrapod vertebrates.
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