ArticleDiabetes2012
Increased inner ear susceptibility to noise injury in mice with streptozotocin-induced diabetes.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Thioredoxin protects against diabetic hearing loss by regulating TOMM22 mediated mitochondrial autophagy in hair cells and inhibiting microglial M1 polarization.Scientific reports · 2026Article
- Associations between diabetes mellitus and sensorineural hearing loss from humans and animal studies.Hearing research · 2024Review
- Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea.Frontiers in cell and developmental biology · 2022Article
- Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions.Neural plasticity · 2021Review
- Synergistic effect of smoking on age-related hearing loss in patients with diabetes.Scientific reports · 2020Article
- Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model.Biomedicines · 2020Article
- Article
- Diabetes and Auditory-Vestibular Pathology.Seminars in hearing · 2019Review
- Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss.International journal of molecular sciences · 2019Article
- Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains.The Journal of veterinary medical science · 2019Article
- The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk.Antioxidants & redox signaling · 2018Review
- Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo.Journal of visualized experiments : JoVE · 2018Article
- Susceptibility of Diabetic Mice to Noise Trauma.BioMed research international · 2018Article
- Hearing Dysfunction inFrontiers in aging neuroscience · 2017Article
- Article
- Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.Neurotoxicity research · 2016Article
- Influences of Diabetes on Hearing Recovery in Noise-Exposed Mice.Journal of audiology & otology · 2015Article
- Article
- Adiponectin deficiency exacerbates age-related hearing impairment.Cell death & disease · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the pathophysiology of diabetes-associated hearing impairment in type 1 diabetes using mice with streptozotocin-induced diabetes (C57BL/6J; male). Hearing function was evaluated 1, 3, and 5 months after induction of diabetes (five diabetic and five control animals per time point) using auditory-evoked brain stem responses (ABRs). Mice (four diabetic and four control) were exposed to loud noise (105 dB) 5 months after induction of diabetes. ABRs were measured before and after noise exposure. Cochlear blood flows were measured by laser-Doppler flowmeter. Spiral ganglion cells (SGCs) were counted. Vessel endothelial cells were observed by CD31 immunostaining. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker in the diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Reduced cochlea blood flows and SGC loss were observed in diabetic mice cochleae after noise exposure. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure, and decreased cochlear blood flow due to sclerosis of the vessels and consequent loss of SGCs are possible mechanisms of hearing impairment in diabetic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.