ArticleThe Journal of cell biology2012
Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast.Molecular cell · 2022Article
- Genomic Data Mining Reveals Abundant Uncharacterized Transporters inJournal of fungi (Basel, Switzerland) · 2022Article
- Article
- Cytoplasmic Transport Machinery of the SPF27 Homologue Num1 in Ustilago maydis.Scientific reports · 2018Article
- A nuclear contortionist: the mitotic migration ofMycology · 2018Review
- Co-delivery of cell-wall-forming enzymes in the same vesicle for coordinated fungal cell wall formation.Nature microbiology · 2016Article
- Nuclear pores enable sustained perinuclear calcium oscillations.BMC systems biology · 2016Article
- Virtual Nuclear Envelope Breakdown and Its Regulators in Fission Yeast Meiosis.Frontiers in cell and developmental biology · 2016Review
- Yeast recombination-based cloning as an efficient way of constructing vectors for Zymoseptoria tritici.Fungal genetics and biology : FG & B · 2015Article
- Article
- Article
- Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes.The Journal of cell biology · 2014Article
- Early endosome motility spatially organizes polysome distribution.The Journal of cell biology · 2014Article
- The SPF27 homologue Num1 connects splicing and kinesin 1-dependent cytoplasmic trafficking in Ustilago maydis.PLoS genetics · 2014Article
- Nuclear division: giving daughters their fair share.Current biology : CB · 2013Article
- Functions and mechanics of dynein motor proteins.Nature reviews. Molecular cell biology · 2013Review
- Inheritance of yeast nuclear pore complexes requires the Nsp1p subcomplex.The Journal of cell biology · 2013Article
- The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1.The Journal of cell biology · 2013Article
- Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum.Eukaryotic cell · 2013Article
- Microtubule-based transport in filamentous fungi.Current opinion in microbiology · 2012Review
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6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Exchange between the nucleus and the cytoplasm is controlled by nuclear pore complexes (NPCs). In animals, NPCs are anchored by the nuclear lamina, which ensures their even distribution and proper organization of chromosomes. Fungi do not possess a lamina and how they arrange their chromosomes and NPCs is unknown. Here, we show that motor-driven motility of NPCs organizes the fungal nucleus. In Ustilago maydis, Aspergillus nidulans, and Saccharomyces cerevisiae fluorescently labeled NPCs showed ATP-dependent movements at ~1.0 µm/s. In S. cerevisiae and U. maydis, NPC motility prevented NPCs from clustering. In budding yeast, NPC motility required F-actin, whereas in U. maydis, microtubules, kinesin-1, and dynein drove pore movements. In the latter, pore clustering resulted in chromatin organization defects and led to a significant reduction in both import and export of GFP reporter proteins. This suggests that fungi constantly rearrange their NPCs and corresponding chromosomes to ensure efficient nuclear transport and thereby overcome the need for a structural lamina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.