ReviewJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2012
Do bisphosphonates cause femoral insufficiency fractures?
Review in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Ulnar fractures with bisphosphonate therapy: a systematic review of published case reports.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Case Report - Short-term Bisphosphonate Use Associated Stress Fractures.Journal of orthopaedic case reports · 2022Article
- Successful treatment for bilateral femoral neck insufficiency fractures: a rare lesion case report and an updated review of the literature.BMC musculoskeletal disorders · 2020Review
- Simultaneous bilateral atypical femoral fracture in a patient receiving denosumab: case report and literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Atypical femoral fracture combined with osteonecrosis of jaw during osteoporosis treatment with bisphosphonate.Journal of bone metabolism · 2014Article
- Treatment of Pathological Bone Fractures in a Patient with McCune-Albright Syndrome.Case reports in endocrinology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, several reports have suggested an association between the use of bisphosphonates and subtrochanteric insufficiency fractures. Research from animal studies and in some cases from histomorphometric data collected from patients provide evidence of a possible pathophysiological mechanism behind this phenomenon. Despite this, it has not yet been possible to confirm a causal relationship. The small number of cases, the lack of consistency in defining these atypical fractures, the absence of homogeneity between studies, and the fact that most data available are derived from retrospective observational studies, are some of the difficulties encountered in the evaluation of evidence. Despite the proven benefit of bisphosphonates at providing protection against osteoporotic fractures, caution should be used before continuing therapy for longer than 5 years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.