Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Brain activation associated with attentional bias in smokers is modulated by a dopamine antagonist.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD).Drug and alcohol dependence · 2018Trial
- Dopamine, urges to smoke, and the relative salience of drug versus non-drug reward.Social cognitive and affective neuroscience · 2015Trial
- Trial
- Individual differences in anterior cingulate activation associated with attentional bias predict cocaine use after treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Optimizing brain functional-structural architecture with cTBS to reduce relapse in alcohol use disorder: a randomized controlled trial.Molecular psychiatry · 2026Article
- Neurobiology of the incubation of drug craving: An update.Pharmacological reviews · 2025Review
- Similarities and Differences in Neuroimaging.Advances in experimental medicine and biology · 2025Review
- Dopamine regulates decision thresholds in human reinforcement learning in males.Nature communications · 2023Article
- Multivariate pattern analysis of the neural correlates of smoking cue attentional bias.Pharmacology, biochemistry, and behavior · 2019Article
- Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- A Framework for Studying the Heterogeneity of Risk Factors in Math Anxiety.Frontiers in behavioral neuroscience · 2018Review
- Optimizing Electrode Montages of Transcranial Direct Current Stimulation for Attentional Bias Modification in Early Abstinent Methamphetamine Users.Frontiers in pharmacology · 2018Article
- Language Learning Enhanced by Massive Multiple Online Role-Playing Games (MMORPGs) and the Underlying Behavioral and Neural Mechanisms.Frontiers in human neuroscience · 2017Review
- Mechanisms of the placebo effect in pain and psychiatric disorders.The pharmacogenomics journal · 2016Review
- What is abnormal about addiction-related attentional biases?Drug and alcohol dependence · 2016Review
- Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: association to striatal D2/D3 receptors.Human brain mapping · 2015Article
- The clinical relevance of neurocognitive measures in addiction.Frontiers in psychiatry · 2014Review
- Individual variation in resisting temptation: implications for addiction.Neuroscience and biobehavioral reviews · 2013Review
- Genetic variations in COMT and DRD2 modulate attentional bias for affective facial expressions.PloS one · 2013Article
- Violence as a source of pleasure or displeasure is associated with specific functional connectivity with the nucleus accumbens.Frontiers in human neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attentional bias in substance-dependent individuals is the tendency to automatically direct the attention to substance-related cues in the environment. Attentional bias is known to be associated with clinical measures such as relapse or successful quitting in smokers. It has been suggested that attentional bias emerges as a consequence of dopaminergic activity evoked by substance-related cues. The current functional magnetic resonance imaging study employed a dopaminergic challenge in order to test whether brain activation associated with attentional bias in smokers could be modulated by a dopamine antagonist. A total of 25 smokers were compared with 24 controls. Participants were scanned twice while performing a pictorial attentional bias task. Haloperidol (2 mg), a selective D2/D3 dopamine antagonist, or placebo was orally administered 4 h before each scanning session in a double-blind randomized cross-over design. Imaging analyses were performed in a priori selected regions of interest. Results showed that smokers had enhanced brain activation compared with controls in the dorsal anterior cingulate cortex (dACC), right dorsolateral prefrontal cortex (r-DLPFC), and left superior parietal lobe (I-SPL) after placebo. Group × medication interactions were found in the dACC and r-DLPFC, with no differences between groups in these regions after haloperidol. The current findings suggest that a pharmacologically induced reduction in dopamine normalizes brain activation associated with attentional bias in the dACC and DLPFC in smokers, probably because salience of these cues is no longer detected when dopamine activity is reduced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.