ArticleJournal of epidemiology2012
Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese.
Article in Journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 12 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 12 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Polymorphism of hOGG1 Gene and Susceptibility to Malignant Neoplasms in People Affected by Long-Term Low-Dose-Rate Exposure.Doklady. Biochemistry and biophysics · 2026Pooled it
- Pooled it
- Pooled it
- Genetic polymorphisms and pancreatic cancer risk: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2019Pooled it
- Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis.Clinical and experimental medicine · 2015Pooled it
- Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Lack of association of XRCC1 rs1799782 genetic polymorphism with risk of pancreatic cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of OGG1 Ser326Cys polymorphism and pancreatic cancer susceptibility: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.PloS one · 2014Pooled it
- Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.PloS one · 2014Pooled it
- Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Pooled it
- Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers.Oncotarget · 2015Article
- Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention.The Yale journal of biology and medicine · 2015Review
- New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Cellular and molecular life sciences : CMLS · 2015Review
- Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer.Frontiers in nutrition · 2015Review
- Association between E-cadherin (CDH1) polymorphisms and pancreatic cancer risk in Han Chinese population.International journal of clinical and experimental pathology · 2015Article
- Association between OGG1 gene single nucleotide polymorphisms and risk of pancreatic cancer in Chinese.Medical oncology (Northwood, London, England) · 2014Article
- Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several reports have described a possible association between DNA repair genes and pancreatic cancer (PC) in smokers, this association has not been fully evaluated in an Asian population. We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese.
methodsThis case-control study compared the frequency of 5 single-nucleotide polymorphisms (SNPs) of BER genes, namely rs1052133 in OGG1, rs1799782 and rs25487 in XRCC1, rs1130409 in APE1, and rs1136410 in PARP1. SNPs were investigated using the TaqMan assay in 185 PC cases and 1465 controls. Associations of PC risk with genetic polymorphisms and gene-environment interaction were examined with an unconditional logistic regression model. Exposure to risk factors was assessed from the results of a self-administered questionnaire. We also performed haplotype-based analysis.
resultsWe observed that the minor allele of rs25487 in XRCC1 was significantly associated with PC risk in the per-allele model (odds ratio = 1.29, CI = 1.01-1.65; trend P = 0.043). Haplotype analysis of XRCC1 also showed a statistically significant association with PC risk. No statistically significant interaction between XRCC1 polymorphisms and smoking status was seen.
conclusionsOur findings suggest that XRCC1 polymorphisms affect PC risk in Japanese.
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