ArticleNeurobiology of disease2013
Limited regional cerebellar dysfunction induces focal dystonia in mice.
Article in Neurobiology of disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Defective cerebellar control of cortical plasticity in writer's cramp.Brain : a journal of neurology · 2013Trial
- Cerebellar α1Cellular and molecular life sciences : CMLS · 2025Article
- Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias.Dystonia (Lausanne, Switzerland) · 2023Article
- Cerebellum Involvement in Dystonia During Associative Motor Learning: Insights From a Data-Driven Spiking Network Model.Frontiers in systems neuroscience · 2022Article
- Discovery of the First Selective MACS pharmacology & translational science · 2021Article
- Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.Molecular genetics and metabolism · 2021Article
- Lessons learned from the syndrome of oculopalatal tremor.Journal of computational neuroscience · 2021Review
- Dystonia and Cerebellum: From Bench to Bedside.Life (Basel, Switzerland) · 2021Review
- Neuronal Activity of Pallidal Versus Cerebellar Receiving Thalamus in Patients with Cervical Dystonia.Cerebellum (London, England) · 2021Article
- Reduced Interhemispheric Coherence after Cerebellar Vermis Output Perturbation.Brain sciences · 2020Article
- Reduced Interhemispheric Coherence in Cerebellar Kainic Acid-Induced Lateralized Dystonia.Frontiers in neurology · 2020Article
- The role of pallidum in the neural integrator model of cervical dystonia.Neurobiology of disease · 2019Article
- Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2.Disease models & mechanisms · 2018Article
- Dopamine Receptor Agonist Treatment of Idiopathic Dystonia: A Reappraisal in Humans and Mice.The Journal of pharmacology and experimental therapeutics · 2018Article
- Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction.Frontiers in cellular neuroscience · 2018Article
- How Many Types of Dystonia? Pathophysiological Considerations.Frontiers in neurology · 2018Review
- Physiology of midbrain head movement neurons in cervical dystonia.Movement disorders : official journal of the Movement Disorder Society · 2017Article
- Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia.Cerebellum (London, England) · 2017Article
- Role of major and brain-specific Sgce isoforms in the pathogenesis of myoclonus-dystonia syndrome.Neurobiology of disease · 2017Article
- Abnormalities of Eye-Hand Coordination in Patients with Writer's Cramp: Possible Role of the Cerebellum.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Dystonia is a complex neurological syndrome broadly characterized by involuntary twisting movements and abnormal postures. The anatomical distribution of the motor symptoms varies among dystonic patients and can range from focal, involving an isolated part of the body, to generalized, involving many body parts. Functional imaging studies of both focal and generalized dystonias in humans often implicate the cerebellum suggesting that similar pathological processes may underlie both. To test this, we exploited tools developed in mice to generate animals with gradients of cerebellar dysfunction. By using conditional genetics to regionally limit cerebellar dysfunction, we found that abnormalities restricted to Purkinje cells were sufficient to cause dystonia. In fact, the extent of cerebellar dysfunction determined the extent of abnormal movements. Dysfunction of the entire cerebellum caused abnormal postures of many body parts, resembling generalized dystonia. More limited regions of dysfunction that were created by electrical stimulation or conditional genetic manipulations produced abnormal movements in an isolated body part, resembling focal dystonia. Overall, these results suggest that focal and generalized dystonias may arise through similar mechanisms and therefore may be approached with similar therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.