ReviewHuman immunology2012
Role of complement and NK cells in antibody mediated rejection.
Review in Human immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- IgG4 donor-specific HLA antibody profile is associated with subclinical rejection in stable pediatric liver recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Trial
- Early glomerular capillary C4d is associated with poor graft function in kidney transplant recipients with preformed donor-specific antibodies.Clinical and experimental nephrology · 2026Observational
- Critical role of complement in antibody mediated rejection in kidney transplantation.World journal of transplantation · 2025Review
- LAG3 regulates antibody responses in a murine model of kidney transplantation.The Journal of clinical investigation · 2025Article
- HLA class II antibody activation of endothelial cells induces M2 macrophage differentiation in peripheral blood.Clinical and experimental nephrology · 2023Article
- Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation.World journal of transplantation · 2022Article
- Microvascular Inflammation of the Renal Allograft: A Reappraisal of the Underlying Mechanisms.Frontiers in immunology · 2022Review
- Article
- Profiling circulating T follicular helper cells and their effects on B cells in post-cardiac transplant recipients.Annals of translational medicine · 2020Article
- Kidney-induced systemic tolerance of heart allografts in mice.JCI insight · 2020Article
- Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.Transplantation · 2020Review
- [The complement system-a "hot topic" not only for kidney diseases].Der Pathologe · 2020Review
- Article
- Management of the sensitized pediatric heart transplant patient.Translational pediatrics · 2019Review
- Redox-Dependent Inflammation in Islet Transplantation Rejection.Frontiers in endocrinology · 2018Review
- Human Cytomegalovirus Infection Increases Both Antibody- and Non-Antibody-Dependent Cellular Reactivity by Natural Killer Cells.Transplantation direct · 2017Article
- Complement in Kidney Transplantation.Frontiers in medicine · 2017Review
- Risk factor for ischemic-type biliary lesion after ABO-incompatible living donor liver transplantation.World journal of gastroenterology · 2016Article
- Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation.Frontiers in immunology · 2016Review
- Transplant biopsy beyond light microscopy.BMC nephrology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Despite extensive research on T cells and potent immunosuppressive regimens that target cellular mediated rejection, few regimens have been proved to be effective on antibody-mediated rejection (AMR), particularly in the chronic setting. C4d deposition in the graft has been proved to be a useful marker for AMR; however, there is an imperfect association between C4d and AMR. While complement has been considered as the main player in acute AMR, the effector mechanisms in chronic AMR are still debated. Recent studies support the role of NK cells and direct effects of antibody on endothelium cells in a mechanism suggesting the presence of a complement-independent pathway. Here, we review the history, currently available systems and progress in experimental animal research. Although there are consistent findings from human and animal research, transposing the experimental results from rodent to human has been hampered by the differences in endothelial functions between species. We briefly describe the findings from patients and compare them with results from animals, to propose a combined perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.