ArticlePediatric rheumatology online journal2012
Diffusion-weighted MRI of bone marrow oedema, soft tissue oedema and synovitis in paediatric patients: feasibility and initial experience.
Article in Pediatric rheumatology online journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- The quiet flame: whole-body MRI and the underestimated burden of pediatric chronic non-bacterial osteomyelitis (CNO).European journal of pediatrics · 2026Article
- Chronic Non-Bacterial Osteomyelitis in Pediatric Patients: Findings from Multiple Centers in Saudi Arabia.Journal of epidemiology and global health · 2025Article
- Chronic non-bacterial osteomyelitis in children- five-year standardized follow-up of a prospective observational cohort in the pre-biological era.Pediatric rheumatology online journal · 2025Observational
- Efficacy of diffusion weighted imaging in sacroiliac joint MRI in children.Northern clinics of Istanbul · 2023Article
- Intravoxel incoherent motion (IVIM) MRI in pediatric patients with synovitis of the knee joint: a prospective pilot study.Pediatric rheumatology online journal · 2022Article
- Benefits of diffusion-weighted imaging in pediatric acute osteoarticular infections.Pediatric radiology · 2022Article
- Diffusion-weighted MR imaging in chronic non-bacterial osteitis: Proof-of-concept of the apparent diffusion coefficient as an outcome measure.Acta radiologica open · 2021Article
- What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century.The British journal of radiology · 2020Review
- New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO.Current rheumatology reports · 2020Review
- How We Manage Bone Marrow Edema-An Interdisciplinary Approach.Journal of clinical medicine · 2020Article
- Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint.World journal of pediatrics : WJP · 2020Article
- Keeping up with the progress in the diagnosis and management of pediatric rheumatic diseases.World journal of pediatrics : WJP · 2020Article
- Mono-exponential and bi-exponential model-based diffusion-weighted MR imaging and IDEAL-IQ sequence for quantitative evaluation of sacroiliitis in patients with ankylosing spondylitis.Clinical rheumatology · 2018Article
- Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.European radiology · 2017Article
- Readout-segmented multi-shot diffusion-weighted MRI of the knee joint in patients with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2017Article
- Clinical applications of advanced magnetic resonance imaging techniques for arthritis evaluation.World journal of orthopedics · 2017Review
- Whole-body MRI in patients with Non-bacterial Osteitis: Radiological findings and correlation with clinical data.European radiology · 2017Article
- Intravoxel incoherent motion magnetic resonance imaging of the knee joint in children with juvenile idiopathic arthritis.Pediatric radiology · 2017Article
- Role of Diffusion Weighted Imaging in Musculoskeletal Infections: Current Perspectives.European radiology · 2017Review
- Association of the apparent diffusion coefficient with maturity in adolescent sacroiliac joints.Journal of magnetic resonance imaging : JMRI · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundMRI has become the mainstay of diagnostic imaging in paediatric rheumatology for lesion detection, differential diagnosis and therapy surveillance. MR imaging of synovitis, in particular, is indispensable for early diagnosis and follow-up in arthritis patients. We used diffusion-weighted MRI (DWI) as a new imaging modality in comparison to standard MRI sequences to study bone marrow oedema, soft-tissue oedema and synovitis in paediatric patients.
methodsA total of 52 patients (mean age 11 ± 5 years) with bone marrow oedema (n = 31), soft-tissue oedema (n = 20) and synovitis (n = 15) were examined with transversal diffusion-weighted single-shot echoplanar imaging in addition to standard MR sequences (T2W TIRM, T1W pre- and post-contrast). Diffusion-weighted images were used for lesion detection and apparent diffusion coefficient (ADC, unit × 10-3 mm2/s) values were measured with ROI technique on ADC maps.
resultsIn 50 of 52 patients, DWI delineated the lesion of interest corresponding to pathological signal increase on standard sequences. Mean ADC was 1.60 ± 0.14 (range 1.38 - 1.99) in osseous lesions, 1.72 ± 0.31 (range 1.43 - 2.56) in soft tissue oedema and 2.82 ± 0.24 (range 2.47 - 3.18) for joint effusion (ANOVA p < 0.001). No significant difference in mean ADC was seen for inflammatory vs. non-inflammatory lesions. Relative signal intensity of oedema was similar for DWI and T2W TIRM. DWI visualised synovial restricted diffusion with a mean ADC of 2.12 ± 0.45 in 12 of 15 patients with synovitis.
conclusionsDiffusion-weighted MRI reliably visualises osseous and soft tissue oedema, as compared to standard sequences. DWI of synovitis is feasible in large joints and presents a novel approach to contrast-free imaging of synovitis. Whole-body DWI for chronic non-bacterial osteomyelitis should be evaluated in future studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.