ArticleMolecular pharmaceutics2012
Ultrasound enhanced matrix metalloproteinase-9 triggered release of contents from echogenic liposomes.
Article in Molecular pharmaceutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy.Biophysics reports · 2020Article
- Echogenic Exosomes as ultrasound contrast agents.Nanoscale advances · 2020Article
- Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses.Journal of controlled release : official journal of the Controlled Release Society · 2018Review
- Role of freeze-drying in the presence of mannitol on the echogenicity of echogenic liposomes.The Journal of the Acoustical Society of America · 2017Article
- [Efficacy of internalized RGD-modified echogenic liposomes in diagnosis and treatment in a mouse model of rheumatoid arthritis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photo-sensitive lipids.Scientific reports · 2017Article
- State of the Art of Stimuli-Responsive Liposomes for Cancer Therapy.Iranian journal of pharmaceutical research : IJPR · 2017Review
- Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects.Therapeutic advances in gastroenterology · 2015Review
- Impulse response method for characterization of echogenic liposomes.The Journal of the Acoustical Society of America · 2015Article
- Polymersome-based drug-delivery strategies for cancer therapeutics.Therapeutic delivery · 2015Review
- pH-triggered echogenicity and contents release from liposomes.Molecular pharmaceutics · 2014Article
- Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells.Biomaterials · 2014Article
- Mmp-9 responsive PEG cleavable nanovesicles for efficient delivery of chemotherapeutics to pancreatic cancer.Molecular pharmaceutics · 2014Article
- Nucleic acid delivery with microbubbles and ultrasound.Advanced drug delivery reviews · 2014Review
- Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery.Computational mechanics · 2014Article
- Stimuli-responsive nanocarriers for drug delivery.Nature materials · 2013Review
- Determination of the interfacial rheological properties of a poly(DL-lactic acid)-encapsulated contrast agent using in vitro attenuation and scattering.Ultrasound in medicine & biology · 2013Article
- Polymer-coated echogenic lipid nanoparticles with dual release triggers.Biomacromolecules · 2013Article
- Current status and prospects for microbubbles in ultrasound theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The extracellular enzyme matrix metalloproteinase-9 (MMP-9) is overexpressed in atherosclerotic plaques and in metastatic cancers. The enzyme is responsible for rupture of the plaques and for the invasion and metastasis of a large number of cancers. The ability of ultrasonic excitation to induce thermal and mechanical effects has been used to release drugs from different carriers. However, the majority of these studies were performed with low frequency ultrasound (LFUS) at kilohertz frequencies. Clinical usage of LFUS excitations will be limited due to harmful biological effects. Herein, we report our results on the release of encapsulated contents from substrate lipopeptide incorporated echogenic liposomes triggered by recombinant human MMP-9. The contents release was further enhanced by the application of diagnostic frequency (3 MHz) ultrasound. The echogenic liposomes were successfully imaged employing a medical ultrasound transducer (4-15 MHz). The conditioned cell culture media from cancer cells (secreting MMP-9) released the encapsulated dye from the liposomes (30-50%), and this release is also increased (50-80%) by applying diagnostic frequency ultrasound (3 MHz) for 3 min. With further developments, these liposomes have the potential to serve as multimodal carriers for triggered release and simultaneous ultrasound imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.