ArticleOxidative medicine and cellular longevity2012
Investigation of effects and mechanisms of total flavonoids of Astragalus and calycosin on human erythroleukemia cells.
Article in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review of anticancer effects of radix astragali.Chinese journal of integrative medicine · 2016Pooled it
- Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment.Pharmaceutical biology · 2024Review
- Investigating the Chemical Profile of Underexplored Parts ofPlants (Basel, Switzerland) · 2024Article
- Unveiling the potential anti-cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research.Cancer medicine · 2024Review
- Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis.Pharmaceutical biology · 2022Article
- Authentication of Shenqi Fuzheng Injection via UPLC-Coupled Ion Mobility-Mass Spectrometry and Chemometrics with Kendrick Mass Defect Filter Data Mining.Molecules (Basel, Switzerland) · 2022Article
- Comparative efficacy of 10 Chinese herbal injections combined with GP regimen chemotherapy for patients with advanced NSCLC a systematic review and network meta-analysis.Journal of Cancer · 2022Article
- Combining the Anticancer and Immunomodulatory Effects ofNutrients · 2021Article
- Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis.Chinese journal of integrative medicine · 2020Review
- Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway.The Journal of international medical research · 2018Article
- Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway.BMC complementary and alternative medicine · 2018Article
- Anti-Aging Implications ofAging and disease · 2017Review
- Identification of bioactives fromJournal of food science and technology · 2017Article
- Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids.Current genomics · 2017Article
- Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines.International journal of molecular sciences · 2016Article
- Article
- A review of recent research progress on the astragalus genus.Molecules (Basel, Switzerland) · 2014Review
- Profiling of hepatocellular carcinoma cell cycle regulating genes targeted by calycosin.BioMed research international · 2013Article
- Flavonoids from the Genus Astragalus: Phytochemistry and Biological Activity.Pharmacognosy reviewsReview
- Antinociceptive activity of Astragalus gummifer gum (gum tragacanth) through the adrenergic system: A in vivo study in mice.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are found in most parts of plants and have been shown to have multiple biological activities such as anticancer, anti-inflammation, antibacteria, antivirus, and immune-stimulation. Existing data showed that the total flavonoids of Astragalus (TFA) can provide biological system with resistance to injury and can possess antimutagenic, atherosclerotic inhibition, and other biological effects. This study investigated the effects of TFA and calycosin (a compound isolated from TFA), on apoptosis induction, and cell cycle of human erythroleukemia cell line K562 by an array of techniques, including proliferation (MTT), PI staining, Annexin V/PI double staining, and RT-PCR. The experimental data showed that TFA and calycosin could inhibit the proliferation of K562 cells. The 50% inhibiting concentrations of TFA and calycosin were 98.63 μg/mL and 130.32 μg/mL, respectively. However, TFA and calycosin could not induce apoptosis in K562 cells, but could increase the number of the cells in the G(0)/G(1) phase. The level of cyclin D1 mRNA in K562 cells decreased after the treatment with TFA and calycosin. This study provides new insights into the functional mechanism of total flavonoids of Astragalus and calycosin on human erythroleukemia cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.