ArticlePLoS neglected tropical diseases2012
Maternal geohelminth infections are associated with an increased susceptibility to geohelminth infection in children: a case-control study.
Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.Clinical and experimental immunology · 2017Trial
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- Risk of acquiringEpidemiology and infection · 2022Article
- Altered Offspring Immunity in Maternal Parasitic Infections.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Understanding Asthma and Allergies by the Lens of Biodiversity and Epigenetic Changes.Frontiers in immunology · 2021Review
- Soil-transmitted helminths and schistosomiasis among pre-school age children in a rural setting of Busia County, Western Kenya: a cross-sectional study of prevalence, and associated exposures.BMC public health · 2020Article
- High prevalence of helminth infections in mother-child pairs from three central provinces of Lao People's Democratic Republic.Parasite epidemiology and control · 2019Article
- Soil-Transmitted Helminthiasis in Children from a Rural Community Taking Part in a Periodic Deworming Program in the Peruvian Amazon.The American journal of tropical medicine and hygiene · 2019Article
- High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.Scientific reports · 2019Article
- HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Soil-Transmitted Helminths in Tropical Australia and Asia.Tropical medicine and infectious disease · 2017Review
- Article
- Maternal Helminth Infection Is Associated With Higher Infant Immunoglobulin A Titers to Antigen in Orally Administered Vaccines.The Journal of infectious diseases · 2016Article
- Soil-Transmitted Helminth Reinfection and Associated Risk Factors among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study.Journal of parasitology research · 2016Article
- Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador.International journal of epidemiology · 2015Article
- Interleukin-10 and soil-transmitted helminth infections in Honduran children.BMC research notes · 2015Article
- Pregnancy and helminth infections.Parasite immunology · 2014Review
- Risk factors for soil-transmitted helminth infections during the first 3 years of life in the tropics; findings from a birth cohort.PLoS neglected tropical diseases · 2014Article
- The role of environmental factors in modulating immune responses in early life.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundChildren of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection. METHODS AND
findingsWe did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7 months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third trimester of pregnancy. The analysis was restricted to households with a documented infection to control for infection risk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR 2.61, 95% CI: 1.88-3.63, p<0.001). This effect was particularly strong in children of mothers with both STH infections (adjusted OR: 5.91, 95% CI: 3.55-9.81, p<0.001). Newborns of infected mothers had greater levels of plasma IL-10 than those of uninfected mothers (p=0.033), and there was evidence that cord blood IL-10 was increased among newborns who became infected later in childhood (p=0.060).
conclusionOur data suggest that maternal STH infections increase susceptibility to infection during early childhood, an effect that was associated with elevated IL-10 in cord plasma.
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Registered trials
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