Evidence map›Paper›PMID 22848765›Full record

ArticlePLoS neglected tropical diseases2012

Partnering parasites: evidence of synergism between heavy Schistosoma haematobium and Plasmodium species infections in Kenyan children.

Lia S Florey, Charles H King, Melissa K Van Dyke, Eric M Muchiri, Peter L Mungai, Peter A Zimmerman, Mark L Wilson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 12 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 12 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  13. Article
  14. Article
  15. Assessment of the selected hematological profiles among malaria andJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Article
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  20. Cytokine profiles among patients co-infected withAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lia S FloreyDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Charles H King
Melissa K Van Dyke
Eric M Muchiri
Peter L Mungai
Peter A Zimmerman
Mark L Wilson
Case Western Reserve University · USUniversity of Michigan–Ann Arbor · USMichigan United · USMinistry of Health · KE

Funding

Eco-epidemiology of Schistosomiasis, Malaria and Polyparasitism in Coastal KenyaR01TW008067 · FIC · CASE WESTERN RESERVE UNIVERSITY · PI KING, CHARLES HARDING, KITRON, URIEL DAN · 2007 to 2011
$2.4M
Changing Dynamics of Anopheline Transmission of Malaria and Filariasis in Papua nR01TW007872 · FIC · CASE WESTERN RESERVE UNIVERSITY · PI ZIMMERMAN, PETER A. · 2006 to 2010
$2.2M
FIC NIH HHS R01 TW007872FIC NIH HHS R01 TW008067FIC NIH HHS R01TW008067NIEHS NIH HHS R01TW/ES01543
6 · The paper itself

Abstract

backgroundResidents of resource-poor tropical countries carry heavy burdens of concurrent parasitic infections, leading to high rates of morbidity and mortality. This study was undertaken to help identify the social and environmental determinants of multiple parasite infection in one such community. METHODOLOGY/PRINCIPAL

findingsResidents of Kingwede, Kenya aged 8 years and older were tested for presence and intensity of S. haematobium and Plasmodium spp. infections in a cross-sectional, household-based, community survey. Using General Estimating Equation (GEE) models, social and environmental determinants associated with patterns of co-infection were identified, with age being one of the most important factors. Children had 9.3 times the odds of co-infection compared to adults (95%CI=5.3-16.3). Even after controlling for age, socio-economic position, and other correlates of co-infection, intense concomitant infections with the two parasites were found to cluster in a subset of individuals: the odds of heavy vs. light S. haematobium infection increased with increasing Plasmodium infection intensity suggesting the importance of unmeasured biological factors in determining intensity of co-infection. CONCLUSIONS/SIGNIFICANCE: Children in this community are more likely to be infected with multiple parasites than are adults and should therefore be targeted for prevention and control interventions. More importantly, heavy infections with multiple parasite species appear to cluster within a subset of individuals. Further studies focusing on these most vulnerable people are warranted.

Indexed as

AdolescentAdultAnimalsChildCoinfectionComorbidityCross-Sectional StudiesFemaleHumansKenyaMalariaMaleMiddle AgedPlasmodiumRisk FactorsSchistosoma haematobium

Identifiers

PMID22848765
PMCPMC3404100
OpenAlexW2094635018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.