ArticlePloS one2012
Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A more complete picture: capturing single nucleotide variant diversity in extended-spectrum beta-lactamase producingMicrobial genomics · 2026Article
- Diversity of Salmonella enterica isolates from urban river and sewage water in Blantyre, Malawi.PLoS neglected tropical diseases · 2025Article
- AfricanmBio · 2025Article
- Notification of bacterial strains made available by the United Kingdom National Collection of Type Cultures in 2022.Access microbiology · 2024Article
- Article
- A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa.Nature communications · 2023Review
- What is the Source of Infections Causing Invasive NontyphoidalOpen forum infectious diseases · 2023Review
- The genomic epidemiology of multi-drug resistant invasive non-typhoidalBMJ global health · 2021Article
- Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa.Nature microbiology · 2021Article
- Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.PLoS neglected tropical diseases · 2020Article
- Pathogenic signature of invasive non-typhoidalHuman vaccines & immunotherapeutics · 2020Review
- High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.PLoS neglected tropical diseases · 2020Article
- Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.PLoS pathogens · 2020Article
- An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.Nature communications · 2019Article
- Ascertaining the burden of invasive Salmonella disease in hospitalised febrile children aged under four years in Blantyre, Malawi.PLoS neglected tropical diseases · 2019Article
- Invasive NontyphoidalEcoSal Plus · 2019Review
- Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants.Infection and immunity · 2018Review
- Role of a single noncoding nucleotide in the evolution of an epidemic African clade ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multi-drug resistant non-typhoidal Salmonella associated with invasive disease in western Kenya.PLoS neglected tropical diseases · 2018Article
- Current perspectives on invasive nontyphoidal Salmonella disease.Current opinion in infectious diseases · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Nontyphoidal Salmonella (NTS) serovars are a common cause of bacteraemia in young children and HIV-infected adults in Malawi and elsewhere in sub-Saharan Africa. These patient populations provide diverse host-immune environments that have the potential to drive bacterial adaptation and evolution. We therefore investigated the diversity of 27 multidrug resistant (MDR) Salmonella Typhimurium strains isolated over 6 years (2002-2008) from HIV-infected adults and children and HIV-uninfected children. Sequence reads from whole-genome sequencing of these isolates using the Illumina GA platform were mapped to the genome of the laboratory strain S. Typhimurium SL1344 excluding homoplastic regions that contained prophage and insertion elements. A phylogenetic tree generated from single nucleotide polymorphisms showed that all 27 strains clustered with the prototypical MDR strain D23580. There was no clustering of strains based on host HIV status or age, suggesting that these susceptible populations acquire S. Typhimurium from common sources or that isolates are transmitted freely between these populations. However, 7/14 of the most recent isolates (2006/2008) formed a distinct clade that branched off 22 SNPs away from the cluster containing earlier isolates. These data suggest that the MDR bacterial population is not static, but is undergoing microevolution which might result in further epidemiology change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.